Disrupted cortical network as a vulnerability marker for obsessive-compulsive disorder
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Peng, Ziwen | - |
dc.contributor.author | Shi, Feng | - |
dc.contributor.author | Shi, Changzheng | - |
dc.contributor.author | Yang, Qiong | - |
dc.contributor.author | Chan, Raymond C. K. | - |
dc.contributor.author | Shen, Dinggang | - |
dc.date.accessioned | 2021-09-05T05:46:17Z | - |
dc.date.available | 2021-09-05T05:46:17Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-09 | - |
dc.identifier.issn | 1863-2653 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/97557 | - |
dc.description.abstract | Morphological alterations of brain structure are generally assumed to be involved in the pathophysiology of obsessive-compulsive disorder (OCD). Yet, little is known about the morphological connectivity properties of structural brain networks in OCD or about the heritability of those morphological connectivity properties. To better understand these properties, we conducted a study that defined three different groups: OCD group with 30 subjects, siblings group with 19 subjects, and matched controls group with 30 subjects. A structural brain network was constructed using 68 cortical regions of each subject within their respective group (i.e., one brain network for each group). Both small-worldness and modularity were measured to reflect the morphological connectivity properties of each constructed structural brain network. When compared to the matched controls, the structural brain networks of patients with OCD indeed exhibited atypical small-worldness and modularity. Specifically, small-worldness showed decreased local efficiency, and modularity showed reduced intra-connectivity in Module III (default mode network) and increased interconnectivity between Module I (executive function) and Module II (cognitive control/spatial). Intriguingly, the structured brain networks of the unaffected siblings showed similar small-worldness and modularity as OCD patients. Based on the atypical structural brain networks observed in OCD patients and their unaffected siblings, abnormal small-worldness and modularity may indicate a candidate endophenotype for OCD. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.subject | COGNITIVE CONTROL | - |
dc.subject | COMMUNITY STRUCTURE | - |
dc.subject | DEFAULT MODE | - |
dc.subject | SCALE | - |
dc.subject | METAANALYSIS | - |
dc.subject | CORTEX | - |
dc.subject | CONNECTIVITY | - |
dc.subject | ORGANIZATION | - |
dc.subject | ARCHITECTURE | - |
dc.subject | MODULARITY | - |
dc.title | Disrupted cortical network as a vulnerability marker for obsessive-compulsive disorder | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shen, Dinggang | - |
dc.identifier.doi | 10.1007/s00429-013-0602-y | - |
dc.identifier.scopusid | 2-s2.0-84906877872 | - |
dc.identifier.wosid | 000341375500021 | - |
dc.identifier.bibliographicCitation | BRAIN STRUCTURE & FUNCTION, v.219, no.5, pp.1801 - 1812 | - |
dc.relation.isPartOf | BRAIN STRUCTURE & FUNCTION | - |
dc.citation.title | BRAIN STRUCTURE & FUNCTION | - |
dc.citation.volume | 219 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1801 | - |
dc.citation.endPage | 1812 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Anatomy & Morphology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Anatomy & Morphology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | COGNITIVE CONTROL | - |
dc.subject.keywordPlus | COMMUNITY STRUCTURE | - |
dc.subject.keywordPlus | DEFAULT MODE | - |
dc.subject.keywordPlus | SCALE | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | CORTEX | - |
dc.subject.keywordPlus | CONNECTIVITY | - |
dc.subject.keywordPlus | ORGANIZATION | - |
dc.subject.keywordPlus | ARCHITECTURE | - |
dc.subject.keywordPlus | MODULARITY | - |
dc.subject.keywordAuthor | Obsessive-compulsive disorder | - |
dc.subject.keywordAuthor | Cortical thickness | - |
dc.subject.keywordAuthor | Brain networks | - |
dc.subject.keywordAuthor | Modularity | - |
dc.subject.keywordAuthor | Small-worldness | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.