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Disrupted cortical network as a vulnerability marker for obsessive-compulsive disorder

Authors
Peng, ZiwenShi, FengShi, ChangzhengYang, QiongChan, Raymond C. K.Shen, Dinggang
Issue Date
9월-2014
Publisher
SPRINGER HEIDELBERG
Keywords
Obsessive-compulsive disorder; Cortical thickness; Brain networks; Modularity; Small-worldness
Citation
BRAIN STRUCTURE & FUNCTION, v.219, no.5, pp.1801 - 1812
Indexed
SCIE
SCOPUS
Journal Title
BRAIN STRUCTURE & FUNCTION
Volume
219
Number
5
Start Page
1801
End Page
1812
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/97557
DOI
10.1007/s00429-013-0602-y
ISSN
1863-2653
Abstract
Morphological alterations of brain structure are generally assumed to be involved in the pathophysiology of obsessive-compulsive disorder (OCD). Yet, little is known about the morphological connectivity properties of structural brain networks in OCD or about the heritability of those morphological connectivity properties. To better understand these properties, we conducted a study that defined three different groups: OCD group with 30 subjects, siblings group with 19 subjects, and matched controls group with 30 subjects. A structural brain network was constructed using 68 cortical regions of each subject within their respective group (i.e., one brain network for each group). Both small-worldness and modularity were measured to reflect the morphological connectivity properties of each constructed structural brain network. When compared to the matched controls, the structural brain networks of patients with OCD indeed exhibited atypical small-worldness and modularity. Specifically, small-worldness showed decreased local efficiency, and modularity showed reduced intra-connectivity in Module III (default mode network) and increased interconnectivity between Module I (executive function) and Module II (cognitive control/spatial). Intriguingly, the structured brain networks of the unaffected siblings showed similar small-worldness and modularity as OCD patients. Based on the atypical structural brain networks observed in OCD patients and their unaffected siblings, abnormal small-worldness and modularity may indicate a candidate endophenotype for OCD.
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