Effect of magnesium hydroxide nanoparticles with rod and plate shape on mechanical and biological properties of poly(L-lactide) composites
- Authors
- Kum, Chang Hun; Seo, Seong Ho; Kang, Sung Nam; Park, Bang Ju; Ahn, Dong June; Joung, Yoon Ki; Han, Dong Keun
- Issue Date
- 9월-2014
- Publisher
- SPRINGER
- Keywords
- poly(L-lactide); magnesium hydroxide; shape; mechanical property; inflammation
- Citation
- MACROMOLECULAR RESEARCH, v.22, no.9, pp.1032 - 1041
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- MACROMOLECULAR RESEARCH
- Volume
- 22
- Number
- 9
- Start Page
- 1032
- End Page
- 1041
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/97644
- DOI
- 10.1007/s13233-014-2140-8
- ISSN
- 1598-5032
- Abstract
- Two kinds of magnesium hydroxide (Mg(OH)(2)) rods (Mg-Rod, 150 and 350 nm in size) and plates (Mg-PL, 60 and 300 nm) were prepared, and blended with poly(L-lactide) (PLLA) to obtain PLLA/Mg(OH)(2) composites to investigate the effect of the shape and size of Mg(OH)(2) particles. The structure, morphology, pH change, thermal and mechanical properties, cytotoxicity, and inflammation of Mg(OH)(2) control and PLLA/Mg(OH)(2) composites were evaluated. PLLA/Mg-Rod150 (30%) composite showed a 50% higher tensile strength and a 45% improved modulus as compared with PLLA/Mg-PL300 30% composite. Although Mg-Rods displayed similar cell viability (above 80%) as compared to Mg-PLs, the expression levels of TNF-alpha from Mg-PL60 gradually increased with increasing concentrations from 1 to 300 mu g. This indicates that Mg-PL60 had a potential cytotoxicity due to endocytosis. In addition, the byproduct of PLLA/Mg-Rods composite was more effectively neutralized than that of the PLLA/Mg-PLs composite, but cell viability and the expression levels of TNF-alpha were similar. Therefore, the use of our PLLA/Mg-Rod composite system would be a promising strategy to prevent the current fatal problems in biomedical applications including biodegradable implants such as stents.
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