Facile Esterification of Alcohols with 2-Acyl-4,5-dichloropyridazin-3(2H)-ones under Friedel-Crafts Conditions
- Authors
- Kim, Bo Ram; Sung, Gi Hyeon; Ryu, Ki Eun; Yoon, Hyo Jae; Lee, Sang-Gyeong; Yoon, Yong-Jin
- Issue Date
- 8월-2014
- Publisher
- GEORG THIEME VERLAG KG
- Keywords
- acylation; esterification; Friedel-Crafts condition; sustainable chemistry; synthetic methods
- Citation
- SYNLETT, v.25, no.13, pp.1909 - 1915
- Indexed
- SCIE
SCOPUS
- Journal Title
- SYNLETT
- Volume
- 25
- Number
- 13
- Start Page
- 1909
- End Page
- 1915
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/97747
- DOI
- 10.1055/s-0034-1378335
- ISSN
- 0936-5214
- Abstract
- This paper describes the esterification of aromatic and aliphatic alcohols by using 2-acyl-4,5-dichloropyridazin-3(2H)-ones as an acyl source under Friedel Crafts conditions. Twelve alcohols were reacted with four 2-acyl-4,5-dichloropyridazin-3(2H)-ones in the presence of AlCl3 in tetrahydrofuran at room temperature to give the corresponding esters in moderate to excellent yields. Thus, 2-acylpyridazin-3(2H)-ones serve as good and atom-economic acyl sources for the esterification of aromatic alcohols under Friedel Crafts conditions, representing a rapid, practical, and efficient method of esterification.
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