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Neuroprotective Xanthones from the Root Bark of Cudrania tricuspidata

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dc.contributor.authorKwon, Jaeyoung-
dc.contributor.authorNguyen Tuan Hiep-
dc.contributor.authorKim, Dong-Woo-
dc.contributor.authorHwang, Bang Yeon-
dc.contributor.authorLee, Hak Ju-
dc.contributor.authorMar, Woongchon-
dc.contributor.authorLee, Dongho-
dc.date.accessioned2021-09-05T06:17:52Z-
dc.date.available2021-09-05T06:17:52Z-
dc.date.created2021-06-15-
dc.date.issued2014-08-
dc.identifier.issn0163-3864-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/97749-
dc.description.abstractSeventeen new prenylated xanthones (1-17) were isolated from an ethyl acetate-soluble extract of root bark of Cudrania tricuspidata together with 17 previously identified xanthones. The structures of the new compounds were elucidated by spectroscopic methods. Six new compounds (3, 7, 8, 9, 15, and 16) and six known compounds (18-23) showed neuroprotective effects against 6-hydroxydopamine-induced cell death in human neuroblastoma SH-SYSY cells, with EC50 values of 0.7-16.6 mu M.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherAMER CHEMICAL SOC-
dc.subjectISOPRENYLATED XANTHONES-
dc.subjectPRENYLATED XANTHONES-
dc.subjectPARKINSONS-DISEASE-
dc.subjectOXIDATIVE STRESS-
dc.subjectMODEL-
dc.subjectCYTOTOXICITY-
dc.subjectCONSTITUENTS-
dc.subjectANTIOXIDANT-
dc.subjectFLAVONOIDS-
dc.subjectCOMPONENTS-
dc.titleNeuroprotective Xanthones from the Root Bark of Cudrania tricuspidata-
dc.typeArticle-
dc.contributor.affiliatedAuthorLee, Dongho-
dc.identifier.doi10.1021/np500364x-
dc.identifier.scopusid2-s2.0-84906673734-
dc.identifier.wosid000340861800018-
dc.identifier.bibliographicCitationJOURNAL OF NATURAL PRODUCTS, v.77, no.8, pp.1893 - 1901-
dc.relation.isPartOfJOURNAL OF NATURAL PRODUCTS-
dc.citation.titleJOURNAL OF NATURAL PRODUCTS-
dc.citation.volume77-
dc.citation.number8-
dc.citation.startPage1893-
dc.citation.endPage1901-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPlant Sciences-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalWebOfScienceCategoryPlant Sciences-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.subject.keywordPlusISOPRENYLATED XANTHONES-
dc.subject.keywordPlusPRENYLATED XANTHONES-
dc.subject.keywordPlusPARKINSONS-DISEASE-
dc.subject.keywordPlusOXIDATIVE STRESS-
dc.subject.keywordPlusMODEL-
dc.subject.keywordPlusCYTOTOXICITY-
dc.subject.keywordPlusCONSTITUENTS-
dc.subject.keywordPlusANTIOXIDANT-
dc.subject.keywordPlusFLAVONOIDS-
dc.subject.keywordPlusCOMPONENTS-
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