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Neuroprotective Xanthones from the Root Bark of Cudrania tricuspidata
- Authors
- Kwon, Jaeyoung; Nguyen Tuan Hiep; Kim, Dong-Woo; Hwang, Bang Yeon; Lee, Hak Ju; Mar, Woongchon; Lee, Dongho
- Issue Date
- 8월-2014
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.77, no.8, pp.1893 - 1901
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 77
- Number
- 8
- Start Page
- 1893
- End Page
- 1901
- ISSN
- 0163-3864
- Abstract
- Seventeen new prenylated xanthones (1-17) were isolated from an ethyl acetate-soluble extract of root bark of Cudrania tricuspidata together with 17 previously identified xanthones. The structures of the new compounds were elucidated by spectroscopic methods. Six new compounds (3, 7, 8, 9, 15, and 16) and six known compounds (18-23) showed neuroprotective effects against 6-hydroxydopamine-induced cell death in human neuroblastoma SH-SYSY cells, with EC50 values of 0.7-16.6 mu M.
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Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
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