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Cruciferous Vegetables, Glutathione S-Transferases, and Implications of Their Interaction to Colorectal Cancer Risk: A Review

Authors
Kim, Jae KyeomShin, Dong-HoonPark, Hui GyuShin, Eui-Cheol
Issue Date
8월-2014
Publisher
KOREAN SOC APPLIED BIOLOGICAL CHEMISTRY
Keywords
cancer prevention; colorectal cancer; cruciferous vegetables; gene-diet interaction; glutathione S-transferases
Citation
JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY, v.57, no.4, pp.511 - 517
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY
Volume
57
Number
4
Start Page
511
End Page
517
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/97759
DOI
10.1007/s13765-014-4014-3
ISSN
1738-2203
Abstract
Globally, colorectal cancer is the third most common type of cancer in men and the second most common in women. As the rate of this cancer increases with the degree of industrialization and urbanization, many researchers emphasize the importance of diets as a decisive factor in the etiology of this cancer. To be specific, the hypothesis that fruit and vegetable intake would act as preventive measurement against colorectal cancer has gained much interest for the general population as well as medical professionals. However, results of epidemiological studies were somewhat inconsistent and showed weak associations in this regard. One possible explanation regarding these controversial results could be due to limited understanding of the interaction between genetic variations and nutrients and their ability to impede cancer development. The objective of this review was to introduce the chemopreventive mechanisms of cruciferous vegetables as well as their active compounds. Furthermore, existing evidence regarding interactions between genetic variations in the key biotransformation enzyme (i.e., glutathione S-transferase) and the effect of the intake of cruciferous vegetables against the risk of colorectal cancer were critically discussed.
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