The Role of Interim F-18-FDG PET/CT in Predicting Early Response to Neoadjuvant Chemotherapy in Breast Cancer
DC Field | Value | Language |
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dc.contributor.author | Pahk, Kisoo | - |
dc.contributor.author | Rhee, Seunghong | - |
dc.contributor.author | Cho, Jaehyuk | - |
dc.contributor.author | Seo, Minhee | - |
dc.contributor.author | Lee, Sinae | - |
dc.contributor.author | Park, Taegyu | - |
dc.contributor.author | Park, Soyeon | - |
dc.contributor.author | Lee, Eunsub | - |
dc.contributor.author | Park, Kyung Hwa | - |
dc.contributor.author | Kim, Chulhan | - |
dc.contributor.author | Eo, Jae Seon | - |
dc.contributor.author | Kim, Sungeun | - |
dc.contributor.author | Choe, Jab Gol | - |
dc.date.accessioned | 2021-09-05T06:39:51Z | - |
dc.date.available | 2021-09-05T06:39:51Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-08 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/97904 | - |
dc.description.abstract | Aim: The aim of this study was to prove the diagnostic value of interim F-18-Fluorodeoxyglucose-positron-emission tomography combined with computed tomography (PET/CT) scan for predicting pathological complete response (pCR) compared to other factors in neoadjuvant chemotheraphy. Patients and Methods: Twenty-seven patients with breast cancer were included in this retrospective study. They all underwent scheduled neoadjuvant chemotherapy. Patients underwent PET/CT at baseline, mid-point (interim), and preoperatively (after completion of chemotherapy). The metabolic response was calculated as follows: Delta Standardized uptake value (SUV)(%)=(lst SUVmax-2nd SUVmax)/1st SUV(max)x 100. Results: The change in SUVmax between baseline and interim PET/CT scans was significantly larger than between interim and preoperative PET/CT scan. An optimal cut-off Delta SUV value of 78.3% was proposed for discriminating patients with pCR from those without pCR. Metabolic CR, defined as a change of SENmax greater than the cut-off value, can predict pCR according to univariate analysis (p=0.012; Relative risk (RR)=25.3). Furthermore, metabolic CR was the most powerful factor for predicting pCR than other possible factors according to multivariate analysis (p=0.003). Conclusion: It is possible to use interim F-18-FDG PET-CT as an effective method to predict early response in patients with breast cancer treated with neoadjuvant chemotherapy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | INT INST ANTICANCER RESEARCH | - |
dc.subject | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject | SURGICAL ADJUVANT BREAST | - |
dc.subject | FDG-PET | - |
dc.subject | PREOPERATIVE CHEMOTHERAPY | - |
dc.subject | PRIMARY TUMOR | - |
dc.subject | PROGNOSIS | - |
dc.subject | CARCINOMA | - |
dc.subject | GRADE | - |
dc.subject | WOMEN | - |
dc.subject | B-18 | - |
dc.title | The Role of Interim F-18-FDG PET/CT in Predicting Early Response to Neoadjuvant Chemotherapy in Breast Cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Kyung Hwa | - |
dc.contributor.affiliatedAuthor | Eo, Jae Seon | - |
dc.contributor.affiliatedAuthor | Kim, Sungeun | - |
dc.contributor.affiliatedAuthor | Choe, Jab Gol | - |
dc.identifier.wosid | 000339773400078 | - |
dc.identifier.bibliographicCitation | ANTICANCER RESEARCH, v.34, no.8, pp.4447 - 4455 | - |
dc.relation.isPartOf | ANTICANCER RESEARCH | - |
dc.citation.title | ANTICANCER RESEARCH | - |
dc.citation.volume | 34 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 4447 | - |
dc.citation.endPage | 4455 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject.keywordPlus | SURGICAL ADJUVANT BREAST | - |
dc.subject.keywordPlus | FDG-PET | - |
dc.subject.keywordPlus | PREOPERATIVE CHEMOTHERAPY | - |
dc.subject.keywordPlus | PRIMARY TUMOR | - |
dc.subject.keywordPlus | PROGNOSIS | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | GRADE | - |
dc.subject.keywordPlus | WOMEN | - |
dc.subject.keywordPlus | B-18 | - |
dc.subject.keywordAuthor | Neoadjuvant chemotherapy | - |
dc.subject.keywordAuthor | response | - |
dc.subject.keywordAuthor | breast cancer | - |
dc.subject.keywordAuthor | FDG PET | - |
dc.subject.keywordAuthor | PET computed tomographic | - |
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