The Role of Interim F-18-FDG PET/CT in Predicting Early Response to Neoadjuvant Chemotherapy in Breast Cancer
- Authors
- Pahk, Kisoo; Rhee, Seunghong; Cho, Jaehyuk; Seo, Minhee; Lee, Sinae; Park, Taegyu; Park, Soyeon; Lee, Eunsub; Park, Kyung Hwa; Kim, Chulhan; Eo, Jae Seon; Kim, Sungeun; Choe, Jab Gol
- Issue Date
- 8월-2014
- Publisher
- INT INST ANTICANCER RESEARCH
- Keywords
- Neoadjuvant chemotherapy; response; breast cancer; FDG PET; PET computed tomographic
- Citation
- ANTICANCER RESEARCH, v.34, no.8, pp.4447 - 4455
- Indexed
- SCIE
SCOPUS
- Journal Title
- ANTICANCER RESEARCH
- Volume
- 34
- Number
- 8
- Start Page
- 4447
- End Page
- 4455
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/97904
- ISSN
- 0250-7005
- Abstract
- Aim: The aim of this study was to prove the diagnostic value of interim F-18-Fluorodeoxyglucose-positron-emission tomography combined with computed tomography (PET/CT) scan for predicting pathological complete response (pCR) compared to other factors in neoadjuvant chemotheraphy. Patients and Methods: Twenty-seven patients with breast cancer were included in this retrospective study. They all underwent scheduled neoadjuvant chemotherapy. Patients underwent PET/CT at baseline, mid-point (interim), and preoperatively (after completion of chemotherapy). The metabolic response was calculated as follows: Delta Standardized uptake value (SUV)(%)=(lst SUVmax-2nd SUVmax)/1st SUV(max)x 100. Results: The change in SUVmax between baseline and interim PET/CT scans was significantly larger than between interim and preoperative PET/CT scan. An optimal cut-off Delta SUV value of 78.3% was proposed for discriminating patients with pCR from those without pCR. Metabolic CR, defined as a change of SENmax greater than the cut-off value, can predict pCR according to univariate analysis (p=0.012; Relative risk (RR)=25.3). Furthermore, metabolic CR was the most powerful factor for predicting pCR than other possible factors according to multivariate analysis (p=0.003). Conclusion: It is possible to use interim F-18-FDG PET-CT as an effective method to predict early response in patients with breast cancer treated with neoadjuvant chemotherapy.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
- College of Medicine > Department of Medical Science > 1. Journal Articles
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