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2-Phenoxychromones and Prenylflavonoids from Epimedium koreanum and Their Inhibitory Effects on LPS-Induced Nitric Oxide and Interleukin-1 beta Production
- Authors
- Jin, Qinghao; Lee, Chul; Lee, Jin Woo; Yeon, Eung Tae; Lee, Dongho; Han, Sang Bae; Hong, Jin Tae; Kim, Youngsoo; Lee, Mi Kyeong; Hwang, Bang Yeon
- Issue Date
- Jul-2014
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.77, no.7, pp.1724 - 1728
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 77
- Number
- 7
- Start Page
- 1724
- End Page
- 1728
- ISSN
- 0163-3864
- Abstract
- Two new 2-phenoxychromones 1 and 2 and two prenylflavonoids 3 and 4 along with 12 known compounds (5-16) were isolated from the CH2Cl2-soluble fraction of a methanol extract of Epimedium koreanum. Compounds 1, 4, 6, 7, 9, 10, 12, and 15 exhibit inhibitory effects on nitric oxide production with IC50 values ranging from 16.8 to 49.3 mu M. Compounds 1, 4, 7, and 12 also showed inhibitory effects on interleukin-1 beta production with IC50 values ranging from 8.6 to 38.9 mu M in RAW 264.7 macrophages.
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Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
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Related Researcher
- Lee, Dong ho
- Department of Plant Biotechnology