Immunogenicity and antigenicity of Plasmodium vivax merozoite surface protein 10
DC Field | Value | Language |
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dc.contributor.author | Cheng, Yang | - |
dc.contributor.author | Wang, Bo | - |
dc.contributor.author | Sattabongkot, Jetsumon | - |
dc.contributor.author | Lim, Chae Seung | - |
dc.contributor.author | Tsuboi, Takafumi | - |
dc.contributor.author | Han, Eun-Taek | - |
dc.date.accessioned | 2021-09-05T07:11:10Z | - |
dc.date.available | 2021-09-05T07:11:10Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-07 | - |
dc.identifier.issn | 0932-0113 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/98009 | - |
dc.description.abstract | Among the proteins involved in the invasion by merozoite, the glycosylphosphatidylinositol-anchored proteins (GPI-APs) are suggested as potential vaccine candidates because of their localization to apical organelles and the surface; these candidates are predicted to play essential roles during invasion. As a GPI-AP, Plasmodium vivax merozoite surface protein 10 (PvMSP-10) induces high antibody titers. However, such high antibody titers have shown no protective efficacy for animals challenged with P. vivax parasites in a previous study. To adequately evaluate the immunogenicity and further characterize PvMSP-10 in order to understand its vaccine potential, we assessed its immunogenicity by immunizing BALB/c mice with cell-free expressed recombinant PvMSP-10 protein. The antigenicity of MSP-10 was analyzed, and we found 42 % sensitivity and 95 % specificity using serum samples from P. vivax-infected Korean patients. The IgG1 and IgG3 were the predominant immunoreactive antibodies against PvMSP-10 in vivax patient sera, and IgG1 and IgG3 and Th1-type cytokines were predominantly secreted in PvMSP-10-immunized mice. We conclude that the immunogenicity and antigenicity of MSP-10 may serve as a potential vaccine against vivax malaria. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | IMMUNE-RESPONSES | - |
dc.subject | MALARIA PARASITES | - |
dc.subject | FALCIPARUM | - |
dc.subject | VACCINE | - |
dc.subject | PROTECTION | - |
dc.subject | INDIVIDUALS | - |
dc.subject | ANTIBODIES | - |
dc.subject | INFECTION | - |
dc.subject | DISCOVERY | - |
dc.subject | EFFICACY | - |
dc.title | Immunogenicity and antigenicity of Plasmodium vivax merozoite surface protein 10 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lim, Chae Seung | - |
dc.identifier.doi | 10.1007/s00436-014-3907-8 | - |
dc.identifier.scopusid | 2-s2.0-84903781590 | - |
dc.identifier.wosid | 000339965000018 | - |
dc.identifier.bibliographicCitation | PARASITOLOGY RESEARCH, v.113, no.7, pp.2559 - 2568 | - |
dc.relation.isPartOf | PARASITOLOGY RESEARCH | - |
dc.citation.title | PARASITOLOGY RESEARCH | - |
dc.citation.volume | 113 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 2559 | - |
dc.citation.endPage | 2568 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Parasitology | - |
dc.relation.journalWebOfScienceCategory | Parasitology | - |
dc.subject.keywordPlus | IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | MALARIA PARASITES | - |
dc.subject.keywordPlus | FALCIPARUM | - |
dc.subject.keywordPlus | VACCINE | - |
dc.subject.keywordPlus | PROTECTION | - |
dc.subject.keywordPlus | INDIVIDUALS | - |
dc.subject.keywordPlus | ANTIBODIES | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | DISCOVERY | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordAuthor | Plasmodium vivax | - |
dc.subject.keywordAuthor | MSP-10 | - |
dc.subject.keywordAuthor | Merozoite surface | - |
dc.subject.keywordAuthor | Immunogenicity | - |
dc.subject.keywordAuthor | Antigenicity | - |
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