Immunogenicity and antigenicity of Plasmodium vivax merozoite surface protein 10
- Authors
- Cheng, Yang; Wang, Bo; Sattabongkot, Jetsumon; Lim, Chae Seung; Tsuboi, Takafumi; Han, Eun-Taek
- Issue Date
- 7월-2014
- Publisher
- SPRINGER
- Keywords
- Plasmodium vivax; MSP-10; Merozoite surface; Immunogenicity; Antigenicity
- Citation
- PARASITOLOGY RESEARCH, v.113, no.7, pp.2559 - 2568
- Indexed
- SCIE
SCOPUS
- Journal Title
- PARASITOLOGY RESEARCH
- Volume
- 113
- Number
- 7
- Start Page
- 2559
- End Page
- 2568
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/98009
- DOI
- 10.1007/s00436-014-3907-8
- ISSN
- 0932-0113
- Abstract
- Among the proteins involved in the invasion by merozoite, the glycosylphosphatidylinositol-anchored proteins (GPI-APs) are suggested as potential vaccine candidates because of their localization to apical organelles and the surface; these candidates are predicted to play essential roles during invasion. As a GPI-AP, Plasmodium vivax merozoite surface protein 10 (PvMSP-10) induces high antibody titers. However, such high antibody titers have shown no protective efficacy for animals challenged with P. vivax parasites in a previous study. To adequately evaluate the immunogenicity and further characterize PvMSP-10 in order to understand its vaccine potential, we assessed its immunogenicity by immunizing BALB/c mice with cell-free expressed recombinant PvMSP-10 protein. The antigenicity of MSP-10 was analyzed, and we found 42 % sensitivity and 95 % specificity using serum samples from P. vivax-infected Korean patients. The IgG1 and IgG3 were the predominant immunoreactive antibodies against PvMSP-10 in vivax patient sera, and IgG1 and IgG3 and Th1-type cytokines were predominantly secreted in PvMSP-10-immunized mice. We conclude that the immunogenicity and antigenicity of MSP-10 may serve as a potential vaccine against vivax malaria.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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