Effects of Chebulic Acid on Advanced Glycation Endproducts-Induced Collagen Cross-Links
DC Field | Value | Language |
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dc.contributor.author | Lee, Ji-young | - |
dc.contributor.author | Oh, Jun-Gu | - |
dc.contributor.author | Kim, Jin Sook | - |
dc.contributor.author | Lee, Kwang-Won | - |
dc.date.accessioned | 2021-09-05T07:16:11Z | - |
dc.date.available | 2021-09-05T07:16:11Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-07 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/98044 | - |
dc.description.abstract | Advanced glycation end-products (AGEs) have been implicated in the development of diabetic complications. We report the antiglycating activity of chebulic acid (CA), isolated from Terminalia chebula on breaking the cross-links of proteins induced by AGEs and inhibiting the formation of AGEs. Aminoguanidine (AG) reduced 50% of glycated bovine serum albumin (BSA) with glycolaldehyde (glycol-BSA)-induced cross-links of collagen at a concentration of 67.8 +/- 2.5 mM, the level of CA required for exerting a similar antiglycating activity was 38.8 +/- 0.5 mu M. Also, the breaking activity on collagen cross-links induced by glycol-BSA was potent with CA (IC50=1.46 +/- 0.05 mM), exhibiting 50-fold stronger breaking activity than with ALT-711, a well-known cross-link breaker (IC50=72.2 +/- 2.4 mM). IC50 values of DPPH. scavenging activity for CA and ascorbic acid (AA) were 39.2 +/- 4.9 and 19.0 +/- 1.29 mu g dry matter (DM) mL(-1), respectively, and ferric reducing and antioxidant power (FRAP) activities for CA and AA were 4.70 +/- 0.06 and 11.4 +/- 0.1 mmol/FeSO4 center dot 7H(2)O/g DM, respectively. The chelating activities of CA, AG and ALT711 on copper-catalyzed oxidation of AA were compared, and in increasing order, ALT-711 (IC50 of 1.92 +/- 0.20 mM)<CA (IC50 of 0.96 +/- 0.07 mM)<AG (0.47 +/- 0.05 mM). Thus, CA could be a breaker as well as an inhibitor of AGE cross-linking, the activity of which may be explained in large part by its chelating and antioxidant activities, suggesting that CA may constitute a promising antiglycating candidate in intervening AGE-mediated diabetic complications. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PHARMACEUTICAL SOC JAPAN | - |
dc.subject | END-PRODUCTS | - |
dc.subject | TERMINALIA-CHEBULA | - |
dc.subject | AGE INHIBITORS | - |
dc.subject | BREAKERS | - |
dc.subject | ARTERIAL | - |
dc.title | Effects of Chebulic Acid on Advanced Glycation Endproducts-Induced Collagen Cross-Links | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Kwang-Won | - |
dc.identifier.doi | 10.1248/bpb.b14-00034 | - |
dc.identifier.scopusid | 2-s2.0-84904654596 | - |
dc.identifier.wosid | 000338269800012 | - |
dc.identifier.bibliographicCitation | BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.37, no.7, pp.1162 - 1167 | - |
dc.relation.isPartOf | BIOLOGICAL & PHARMACEUTICAL BULLETIN | - |
dc.citation.title | BIOLOGICAL & PHARMACEUTICAL BULLETIN | - |
dc.citation.volume | 37 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1162 | - |
dc.citation.endPage | 1167 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | END-PRODUCTS | - |
dc.subject.keywordPlus | TERMINALIA-CHEBULA | - |
dc.subject.keywordPlus | AGE INHIBITORS | - |
dc.subject.keywordPlus | BREAKERS | - |
dc.subject.keywordPlus | ARTERIAL | - |
dc.subject.keywordAuthor | chebulic acid | - |
dc.subject.keywordAuthor | Terminalia chebula | - |
dc.subject.keywordAuthor | chelating activity | - |
dc.subject.keywordAuthor | collagen cross-link | - |
dc.subject.keywordAuthor | advanced glycation end-product | - |
dc.subject.keywordAuthor | antiglycation effect | - |
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