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Pyranocoumarins from Glehnia littoralis inhibit the LPS-induced NO production in macrophage RAW 264.7 cells
- Authors
- Lee, Jin Woo; Lee, Chul; Jin, Qinghao; Yeon, Eung Tae; Lee, Dongho; Kim, Soo-Young; Han, Sang Bae; Hong, Jin Tae; Lee, Mi Kyeong; Hwang, Bang Yeon
- Issue Date
- 15-Jun-2014
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Glehnia littoralis; Apiaceae; Dihydropyranocoumarin; Nitric oxide production inhibitor
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.24, no.12, pp.2717 - 2719
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 24
- Number
- 12
- Start Page
- 2717
- End Page
- 2719
- ISSN
- 0960-894X
- Abstract
- A new dihydropyranocoumarin, (+)-cis-(30S, 40S)-diisobutyrylkhellactone (1), together with five known compounds, 3'-senecioyl-4'-acetylkhellactone (2), 3'-isovaleryl-4'-acetylkhellactone (3), 3',4'-disenecioylkhellactone (4), 3'-isovaleryl-4'-senecioylkhellactone (5), and 3',4'-diisovalerylkhellactone (6), was isolated from Glehnia littoralis. Their chemical structures were elucidated based on the spectroscopic data interpretation, particularly 1D and 2D NMR data including HMQC and HMBC. All the isolated compounds showed the potential to inhibit LPS-induced nitric oxide production in RAW 264.7 cells with IC50 values ranging from 7.4 to 44.3 mu M. (C) 2014 Elsevier Ltd. All rights reserved.
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Related Researcher
- Lee, Dong ho
- Department of Plant Biotechnology