Two-Photon Probe for Cu2+ with an Internal Reference: Quantitative Estimation of Cu2+ in Human Tissues by Two-Photon Microscopy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Dong Eun | - |
dc.contributor.author | Lim, Chang Su | - |
dc.contributor.author | Kim, Ji Yeon | - |
dc.contributor.author | Kim, Eun Sun | - |
dc.contributor.author | Chun, Hoon Jai | - |
dc.contributor.author | Cho, Bong Rae | - |
dc.date.accessioned | 2021-09-05T08:06:51Z | - |
dc.date.available | 2021-09-05T08:06:51Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-06-03 | - |
dc.identifier.issn | 0003-2700 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/98260 | - |
dc.description.abstract | Copper ions play a crucial role in living systems as cofactors of numerous metalloenzymes. To quantitatively estimate the Cu2+ concentration in human tissue, we have developed a two-photon (TP) probe with an internal reference (ACCu2) that shows significant TP action cross-section and high selectivity for Cu2+ and can quantitatively estimate the Cu2+ concentration in human colon tissues by dual-color two-photon microscopy (TPM) imaging with minimum interference from other competing metal ions or pH and minimum cytotoxicity and photostability problems. The Cu2+ concentrations in human normal colon, polyp, and colon cancer tissues were found to be 8.3 +/- 0.3, 13 +/- 2, and 22 +/- 3 mu M, respectively. This result suggests that ACCu2 may be useful for the diagnosis of human colon cancer. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | RATIOMETRIC FLUORESCENT SENSOR | - |
dc.subject | METAL-IONS | - |
dc.subject | COPPER IONS | - |
dc.subject | DISEASE | - |
dc.subject | MECHANISMS | - |
dc.subject | ALZHEIMERS | - |
dc.subject | EXCITATION | - |
dc.subject | CELLS | - |
dc.subject | ZINC | - |
dc.title | Two-Photon Probe for Cu2+ with an Internal Reference: Quantitative Estimation of Cu2+ in Human Tissues by Two-Photon Microscopy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Eun Sun | - |
dc.contributor.affiliatedAuthor | Chun, Hoon Jai | - |
dc.contributor.affiliatedAuthor | Cho, Bong Rae | - |
dc.identifier.doi | 10.1021/ac500329k | - |
dc.identifier.scopusid | 2-s2.0-84901756404 | - |
dc.identifier.wosid | 000336953100024 | - |
dc.identifier.bibliographicCitation | ANALYTICAL CHEMISTRY, v.86, no.11, pp.5353 - 5359 | - |
dc.relation.isPartOf | ANALYTICAL CHEMISTRY | - |
dc.citation.title | ANALYTICAL CHEMISTRY | - |
dc.citation.volume | 86 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 5353 | - |
dc.citation.endPage | 5359 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.subject.keywordPlus | RATIOMETRIC FLUORESCENT SENSOR | - |
dc.subject.keywordPlus | METAL-IONS | - |
dc.subject.keywordPlus | COPPER IONS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | ALZHEIMERS | - |
dc.subject.keywordPlus | EXCITATION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | ZINC | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.