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Two-Photon Probe for Cu2+ with an Internal Reference: Quantitative Estimation of Cu2+ in Human Tissues by Two-Photon Microscopy

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dc.contributor.authorKang, Dong Eun-
dc.contributor.authorLim, Chang Su-
dc.contributor.authorKim, Ji Yeon-
dc.contributor.authorKim, Eun Sun-
dc.contributor.authorChun, Hoon Jai-
dc.contributor.authorCho, Bong Rae-
dc.date.accessioned2021-09-05T08:06:51Z-
dc.date.available2021-09-05T08:06:51Z-
dc.date.created2021-06-15-
dc.date.issued2014-06-03-
dc.identifier.issn0003-2700-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/98260-
dc.description.abstractCopper ions play a crucial role in living systems as cofactors of numerous metalloenzymes. To quantitatively estimate the Cu2+ concentration in human tissue, we have developed a two-photon (TP) probe with an internal reference (ACCu2) that shows significant TP action cross-section and high selectivity for Cu2+ and can quantitatively estimate the Cu2+ concentration in human colon tissues by dual-color two-photon microscopy (TPM) imaging with minimum interference from other competing metal ions or pH and minimum cytotoxicity and photostability problems. The Cu2+ concentrations in human normal colon, polyp, and colon cancer tissues were found to be 8.3 +/- 0.3, 13 +/- 2, and 22 +/- 3 mu M, respectively. This result suggests that ACCu2 may be useful for the diagnosis of human colon cancer.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherAMER CHEMICAL SOC-
dc.subjectRATIOMETRIC FLUORESCENT SENSOR-
dc.subjectMETAL-IONS-
dc.subjectCOPPER IONS-
dc.subjectDISEASE-
dc.subjectMECHANISMS-
dc.subjectALZHEIMERS-
dc.subjectEXCITATION-
dc.subjectCELLS-
dc.subjectZINC-
dc.titleTwo-Photon Probe for Cu2+ with an Internal Reference: Quantitative Estimation of Cu2+ in Human Tissues by Two-Photon Microscopy-
dc.typeArticle-
dc.contributor.affiliatedAuthorKim, Eun Sun-
dc.contributor.affiliatedAuthorChun, Hoon Jai-
dc.contributor.affiliatedAuthorCho, Bong Rae-
dc.identifier.doi10.1021/ac500329k-
dc.identifier.scopusid2-s2.0-84901756404-
dc.identifier.wosid000336953100024-
dc.identifier.bibliographicCitationANALYTICAL CHEMISTRY, v.86, no.11, pp.5353 - 5359-
dc.relation.isPartOfANALYTICAL CHEMISTRY-
dc.citation.titleANALYTICAL CHEMISTRY-
dc.citation.volume86-
dc.citation.number11-
dc.citation.startPage5353-
dc.citation.endPage5359-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Analytical-
dc.subject.keywordPlusRATIOMETRIC FLUORESCENT SENSOR-
dc.subject.keywordPlusMETAL-IONS-
dc.subject.keywordPlusCOPPER IONS-
dc.subject.keywordPlusDISEASE-
dc.subject.keywordPlusMECHANISMS-
dc.subject.keywordPlusALZHEIMERS-
dc.subject.keywordPlusEXCITATION-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusZINC-
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