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Two-Photon Probe for Cu2+ with an Internal Reference: Quantitative Estimation of Cu2+ in Human Tissues by Two-Photon Microscopy

Authors
Kang, Dong EunLim, Chang SuKim, Ji YeonKim, Eun SunChun, Hoon JaiCho, Bong Rae
Issue Date
3-6월-2014
Publisher
AMER CHEMICAL SOC
Citation
ANALYTICAL CHEMISTRY, v.86, no.11, pp.5353 - 5359
Indexed
SCIE
SCOPUS
Journal Title
ANALYTICAL CHEMISTRY
Volume
86
Number
11
Start Page
5353
End Page
5359
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/98260
DOI
10.1021/ac500329k
ISSN
0003-2700
Abstract
Copper ions play a crucial role in living systems as cofactors of numerous metalloenzymes. To quantitatively estimate the Cu2+ concentration in human tissue, we have developed a two-photon (TP) probe with an internal reference (ACCu2) that shows significant TP action cross-section and high selectivity for Cu2+ and can quantitatively estimate the Cu2+ concentration in human colon tissues by dual-color two-photon microscopy (TPM) imaging with minimum interference from other competing metal ions or pH and minimum cytotoxicity and photostability problems. The Cu2+ concentrations in human normal colon, polyp, and colon cancer tissues were found to be 8.3 +/- 0.3, 13 +/- 2, and 22 +/- 3 mu M, respectively. This result suggests that ACCu2 may be useful for the diagnosis of human colon cancer.
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