Ethnic differences in the association of the glutathione S-transferase T1 (GSTT1) null genotype and risk of gastric carcinoma: a systematic review and meta-analysis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoon, Jeongmin | - |
dc.contributor.author | Hyun, Myung-Han | - |
dc.contributor.author | Yang, Jong-Pill | - |
dc.contributor.author | Park, Min-Jeong | - |
dc.contributor.author | Park, Sungsoo | - |
dc.date.accessioned | 2021-09-05T08:21:41Z | - |
dc.date.available | 2021-09-05T08:21:41Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-06 | - |
dc.identifier.issn | 0301-4851 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/98358 | - |
dc.description.abstract | We performed a systematic review and meta-analysis of the association between the glutathione S-transferase T1 (GSTT1) deletion polymorphism and gastric cancer risk in populations from different ethnic backgrounds, based on a comprehensive literature search of the MEDLINE, EMBASE, and COCHRANE libraries. Thirty-six individual case-control studies comprising 7,689 gastric cancer cases and 12,445 controls were included in our meta-analysis. Overall, the GSTT1 null genotype appeared to increase gastric cancer risk (OR 1.17, 95 % CI 1.06-1.31, p = 0.003). While Caucasian populations showed an association between the GSTT1 deletion polymorphism and gastric cancer risk (OR 1.27, 95 % CI 1.05-1.52, p = 0.01), Asian populations did not show such an association (p = 0.11). When stratified by quality assessment scores, a significant association between the GSTT1 deletion polymorphism and gastric cancer risk was observed only in the Caucasian high quality subgroup (OR 1.27 95 % CI 1.01-1.60, p = 0.05). Null genotypes for both GSTT1 and GSTM1 deletion polymorphisms also increased gastric cancer risk (OR 1.37, 95 % CI 1.04-1.80, p = 0.03). Our study suggests that the GSTT1 null genotype is associated with a significant increase in gastric cancer risk in Caucasians, but not in Asians. Further well-designed studies are required to confirm the association between GSTT1 polymorphisms and gastric cancer risk in relation to various clinicopathological factors in different ethnic groups, especially Caucasians. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | HELICOBACTER-PYLORI INFECTION | - |
dc.subject | GENETIC POLYMORPHISMS | - |
dc.subject | CANCER RISK | - |
dc.subject | METABOLIC GENES | - |
dc.subject | STOMACH-CANCER | - |
dc.subject | INTERLEUKIN-1 POLYMORPHISMS | - |
dc.subject | POOLED-ANALYSES | - |
dc.subject | TOBACCO-SMOKE | - |
dc.subject | META-ANALYSES | - |
dc.subject | DNA-REPAIR | - |
dc.title | Ethnic differences in the association of the glutathione S-transferase T1 (GSTT1) null genotype and risk of gastric carcinoma: a systematic review and meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Sungsoo | - |
dc.identifier.doi | 10.1007/s11033-014-3254-y | - |
dc.identifier.scopusid | 2-s2.0-84902371011 | - |
dc.identifier.wosid | 000336404500036 | - |
dc.identifier.bibliographicCitation | MOLECULAR BIOLOGY REPORTS, v.41, no.6, pp.3867 - 3879 | - |
dc.relation.isPartOf | MOLECULAR BIOLOGY REPORTS | - |
dc.citation.title | MOLECULAR BIOLOGY REPORTS | - |
dc.citation.volume | 41 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 3867 | - |
dc.citation.endPage | 3879 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | HELICOBACTER-PYLORI INFECTION | - |
dc.subject.keywordPlus | GENETIC POLYMORPHISMS | - |
dc.subject.keywordPlus | CANCER RISK | - |
dc.subject.keywordPlus | METABOLIC GENES | - |
dc.subject.keywordPlus | STOMACH-CANCER | - |
dc.subject.keywordPlus | INTERLEUKIN-1 POLYMORPHISMS | - |
dc.subject.keywordPlus | POOLED-ANALYSES | - |
dc.subject.keywordPlus | TOBACCO-SMOKE | - |
dc.subject.keywordPlus | META-ANALYSES | - |
dc.subject.keywordPlus | DNA-REPAIR | - |
dc.subject.keywordAuthor | Glutathione S-transferase T1 | - |
dc.subject.keywordAuthor | GSTT1 | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Genetic | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Single nucleotide | - |
dc.subject.keywordAuthor | Risk | - |
dc.subject.keywordAuthor | Stomach neoplasms | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.