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Ethnic differences in the association of the glutathione S-transferase T1 (GSTT1) null genotype and risk of gastric carcinoma: a systematic review and meta-analysis

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dc.contributor.authorYoon, Jeongmin-
dc.contributor.authorHyun, Myung-Han-
dc.contributor.authorYang, Jong-Pill-
dc.contributor.authorPark, Min-Jeong-
dc.contributor.authorPark, Sungsoo-
dc.date.accessioned2021-09-05T08:21:41Z-
dc.date.available2021-09-05T08:21:41Z-
dc.date.created2021-06-15-
dc.date.issued2014-06-
dc.identifier.issn0301-4851-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/98358-
dc.description.abstractWe performed a systematic review and meta-analysis of the association between the glutathione S-transferase T1 (GSTT1) deletion polymorphism and gastric cancer risk in populations from different ethnic backgrounds, based on a comprehensive literature search of the MEDLINE, EMBASE, and COCHRANE libraries. Thirty-six individual case-control studies comprising 7,689 gastric cancer cases and 12,445 controls were included in our meta-analysis. Overall, the GSTT1 null genotype appeared to increase gastric cancer risk (OR 1.17, 95 % CI 1.06-1.31, p = 0.003). While Caucasian populations showed an association between the GSTT1 deletion polymorphism and gastric cancer risk (OR 1.27, 95 % CI 1.05-1.52, p = 0.01), Asian populations did not show such an association (p = 0.11). When stratified by quality assessment scores, a significant association between the GSTT1 deletion polymorphism and gastric cancer risk was observed only in the Caucasian high quality subgroup (OR 1.27 95 % CI 1.01-1.60, p = 0.05). Null genotypes for both GSTT1 and GSTM1 deletion polymorphisms also increased gastric cancer risk (OR 1.37, 95 % CI 1.04-1.80, p = 0.03). Our study suggests that the GSTT1 null genotype is associated with a significant increase in gastric cancer risk in Caucasians, but not in Asians. Further well-designed studies are required to confirm the association between GSTT1 polymorphisms and gastric cancer risk in relation to various clinicopathological factors in different ethnic groups, especially Caucasians.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherSPRINGER-
dc.subjectHELICOBACTER-PYLORI INFECTION-
dc.subjectGENETIC POLYMORPHISMS-
dc.subjectCANCER RISK-
dc.subjectMETABOLIC GENES-
dc.subjectSTOMACH-CANCER-
dc.subjectINTERLEUKIN-1 POLYMORPHISMS-
dc.subjectPOOLED-ANALYSES-
dc.subjectTOBACCO-SMOKE-
dc.subjectMETA-ANALYSES-
dc.subjectDNA-REPAIR-
dc.titleEthnic differences in the association of the glutathione S-transferase T1 (GSTT1) null genotype and risk of gastric carcinoma: a systematic review and meta-analysis-
dc.typeArticle-
dc.contributor.affiliatedAuthorPark, Sungsoo-
dc.identifier.doi10.1007/s11033-014-3254-y-
dc.identifier.scopusid2-s2.0-84902371011-
dc.identifier.wosid000336404500036-
dc.identifier.bibliographicCitationMOLECULAR BIOLOGY REPORTS, v.41, no.6, pp.3867 - 3879-
dc.relation.isPartOfMOLECULAR BIOLOGY REPORTS-
dc.citation.titleMOLECULAR BIOLOGY REPORTS-
dc.citation.volume41-
dc.citation.number6-
dc.citation.startPage3867-
dc.citation.endPage3879-
dc.type.rimsART-
dc.type.docTypeReview-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.subject.keywordPlusHELICOBACTER-PYLORI INFECTION-
dc.subject.keywordPlusGENETIC POLYMORPHISMS-
dc.subject.keywordPlusCANCER RISK-
dc.subject.keywordPlusMETABOLIC GENES-
dc.subject.keywordPlusSTOMACH-CANCER-
dc.subject.keywordPlusINTERLEUKIN-1 POLYMORPHISMS-
dc.subject.keywordPlusPOOLED-ANALYSES-
dc.subject.keywordPlusTOBACCO-SMOKE-
dc.subject.keywordPlusMETA-ANALYSES-
dc.subject.keywordPlusDNA-REPAIR-
dc.subject.keywordAuthorGlutathione S-transferase T1-
dc.subject.keywordAuthorGSTT1-
dc.subject.keywordAuthorPolymorphism-
dc.subject.keywordAuthorGenetic-
dc.subject.keywordAuthorPolymorphism-
dc.subject.keywordAuthorSingle nucleotide-
dc.subject.keywordAuthorRisk-
dc.subject.keywordAuthorStomach neoplasms-
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