Ethnic differences in the association of the glutathione S-transferase T1 (GSTT1) null genotype and risk of gastric carcinoma: a systematic review and meta-analysis
- Authors
- Yoon, Jeongmin; Hyun, Myung-Han; Yang, Jong-Pill; Park, Min-Jeong; Park, Sungsoo
- Issue Date
- 6월-2014
- Publisher
- SPRINGER
- Keywords
- Glutathione S-transferase T1; GSTT1; Polymorphism; Genetic; Polymorphism; Single nucleotide; Risk; Stomach neoplasms
- Citation
- MOLECULAR BIOLOGY REPORTS, v.41, no.6, pp.3867 - 3879
- Indexed
- SCIE
SCOPUS
- Journal Title
- MOLECULAR BIOLOGY REPORTS
- Volume
- 41
- Number
- 6
- Start Page
- 3867
- End Page
- 3879
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/98358
- DOI
- 10.1007/s11033-014-3254-y
- ISSN
- 0301-4851
- Abstract
- We performed a systematic review and meta-analysis of the association between the glutathione S-transferase T1 (GSTT1) deletion polymorphism and gastric cancer risk in populations from different ethnic backgrounds, based on a comprehensive literature search of the MEDLINE, EMBASE, and COCHRANE libraries. Thirty-six individual case-control studies comprising 7,689 gastric cancer cases and 12,445 controls were included in our meta-analysis. Overall, the GSTT1 null genotype appeared to increase gastric cancer risk (OR 1.17, 95 % CI 1.06-1.31, p = 0.003). While Caucasian populations showed an association between the GSTT1 deletion polymorphism and gastric cancer risk (OR 1.27, 95 % CI 1.05-1.52, p = 0.01), Asian populations did not show such an association (p = 0.11). When stratified by quality assessment scores, a significant association between the GSTT1 deletion polymorphism and gastric cancer risk was observed only in the Caucasian high quality subgroup (OR 1.27 95 % CI 1.01-1.60, p = 0.05). Null genotypes for both GSTT1 and GSTM1 deletion polymorphisms also increased gastric cancer risk (OR 1.37, 95 % CI 1.04-1.80, p = 0.03). Our study suggests that the GSTT1 null genotype is associated with a significant increase in gastric cancer risk in Caucasians, but not in Asians. Further well-designed studies are required to confirm the association between GSTT1 polymorphisms and gastric cancer risk in relation to various clinicopathological factors in different ethnic groups, especially Caucasians.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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