The Effect of Alendronate-Loaded Polycarprolactone Nanofibrous Scaffolds on Osteogenic Differentiation of Adipose-Derived Stem Cells in Bone Tissue Regeneration
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yun, Young-Pil | - |
dc.contributor.author | Kim, Seung-Ju | - |
dc.contributor.author | Lim, Youn-Mook | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.contributor.author | Kim, Hak-Jun | - |
dc.contributor.author | Jeong, Sung-In | - |
dc.contributor.author | Kim, Sung Eun | - |
dc.contributor.author | Song, Hae-Ryong | - |
dc.date.accessioned | 2021-09-05T08:26:29Z | - |
dc.date.available | 2021-09-05T08:26:29Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-06 | - |
dc.identifier.issn | 1550-7033 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/98390 | - |
dc.description.abstract | The osteogenic effect of culturing adipose-derived stem cells (ADSCs) on alendronate (Aln)-loaded polycarprolactone (PCL) nanofibrous scaffolds was evaluated by examining alkaline phosphatase (ALP) activity, calcium content, and expression of osteogenic differentiation genes in vitro. The 10% Aln/PCL nanofibrous scaffolds showed more ALP activity, mineralization, and osteocalcin and osteopontin mRNA than the 1% or 5% Aln/PCL nanofibrous scaffolds. The capacity of Aln/PCL nanofibrous scaffolds to regenerate new bone was studied in a rat calvarial defect model. New bone formation in vivo was evaluated by radiography, micro-computed tomography, and histological analysis. At 8 weeks after implantation, Aln/PCL scaffolds had a positive effect on bone regeneration and matrix formation. These results suggested that Aln/PCL nanofibrous scaffolds enhanced the osteogenic differentiation of ADSCs in vitro and bone formation in vivo. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER SCIENTIFIC PUBLISHERS | - |
dc.subject | PCL | - |
dc.subject | COLLAGEN | - |
dc.subject | FIBERS | - |
dc.subject | POLY(L-LACTIDE-CO-EPSILON-CAPROLACTONE) | - |
dc.subject | HYDROXYAPATITE | - |
dc.subject | PROLIFERATION | - |
dc.subject | DEGRADATION | - |
dc.subject | EXPRESSION | - |
dc.subject | CELLULOSE | - |
dc.subject | DELIVERY | - |
dc.title | The Effect of Alendronate-Loaded Polycarprolactone Nanofibrous Scaffolds on Osteogenic Differentiation of Adipose-Derived Stem Cells in Bone Tissue Regeneration | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hak-Jun | - |
dc.contributor.affiliatedAuthor | Song, Hae-Ryong | - |
dc.identifier.doi | 10.1166/jbn.2014.1819 | - |
dc.identifier.scopusid | 2-s2.0-84898406247 | - |
dc.identifier.wosid | 000328729400017 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, v.10, no.6, pp.1080 - 1090 | - |
dc.relation.isPartOf | JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | - |
dc.citation.title | JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | - |
dc.citation.volume | 10 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1080 | - |
dc.citation.endPage | 1090 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | PCL | - |
dc.subject.keywordPlus | COLLAGEN | - |
dc.subject.keywordPlus | FIBERS | - |
dc.subject.keywordPlus | POLY(L-LACTIDE-CO-EPSILON-CAPROLACTONE) | - |
dc.subject.keywordPlus | HYDROXYAPATITE | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CELLULOSE | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordAuthor | Polycarprolactone | - |
dc.subject.keywordAuthor | Alendronate | - |
dc.subject.keywordAuthor | Nanofiber | - |
dc.subject.keywordAuthor | Adipose-Derived Stem Cells | - |
dc.subject.keywordAuthor | Bone Regeneration | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.