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A thermosensitive chitosan-based hydrogel for controlled release of insulin
- Authors
- Gao, Ting-Ting; Kong, Ming; Cheng, Xiao-Jie; Xia, Gui-Xue; Gao, Yuan-Yuan; Chen, Xi-Guang; Cha, Dong Su; Park, Hyun Jin
- Issue Date
- 6월-2014
- Publisher
- HIGHER EDUCATION PRESS
- Keywords
- hydroxybutyl chitosan; hydrogel; thermosensitive; insulin; controlled release
- Citation
- FRONTIERS OF MATERIALS SCIENCE, v.8, no.2, pp.142 - 149
- Indexed
- SCIE
SCOPUS
- Journal Title
- FRONTIERS OF MATERIALS SCIENCE
- Volume
- 8
- Number
- 2
- Start Page
- 142
- End Page
- 149
- ISSN
- 2095-025X
- Abstract
- Present study aims at synthesizing a thermosensitive hydrogel for controlled release of insulin. According to a modified method, hydroxybutyl chitosan (HBC) hydrogel possessed thermal sensitivity is prepared which can form hydrogel at over 25 degrees C. The HBC hydrogel is non-cytotoxic to mice fibroblasts cells (L929). Insulin is 100% entrapped in the hydrogel, 38% of which is released in vitro from the concentration of 5% hydrogel after 48 h, whereas by enzymolysis with lysozyme, 80% of the total insulin is released after 48 h. This study suggests that HBC hydrogel could be utilized for controlled release of insulin in a non-invasive manner.
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Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
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