The effect of intracellular trafficking of CD1d on the formation of TCR repertoire of NKT cells
DC Field | Value | Language |
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dc.contributor.author | Shin, Jung Hoon | - |
dc.contributor.author | Park, Se-Ho | - |
dc.date.accessioned | 2021-09-05T08:39:24Z | - |
dc.date.available | 2021-09-05T08:39:24Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-05-31 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/98481 | - |
dc.description.abstract | CD1 molecules belong to non-polymorphic MHC class I-like proteins and present lipid antigens to T cells. Five different CD1 genes (CD1a-e) have been identified and classified into two groups. Group 1 include CD1a-c and present pathogenic lipid antigens to alpha beta T cells reminiscence of peptide antigen presentation by MHC-I molecules. CD1d is the only member of Group 2 and presents foreign and self lipid antigens to a specialized subset of alpha beta T cells, NKT cells. NKT cells are involved in diverse immune responses through prompt and massive production of cytokines. CD1d-dependent NKT cells are categorized upon the usage of their T cell receptors. A major subtype of NKT cells (type I) is invariant NKT cells which utilize invariant V alpha 14-J alpha 18 TCR alpha chain in mouse. The remaining NKT cells (type II) utilize diverse TCR alpha chains. Engineered CD1d molecules with modified intracellular trafficking produce either type I or type II NKT cell-defects suggesting the lipid antigens for each subtypes of NKT cells are processed/generated in different intracellular compartments. Since the usage of TCR by a T cell is the result of antigen-driven selection, the intracellular metabolic pathways of lipid antigen are a key in forming the functional NKT cell repertoire. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY | - |
dc.subject | KILLER T-CELLS | - |
dc.subject | C-GLYCOSIDE ANALOG | - |
dc.subject | LIGAND ALPHA-GALACTOSYLCERAMIDE | - |
dc.subject | TRIGLYCERIDE TRANSFER PROTEIN | - |
dc.subject | CLASS-II MOLECULES | - |
dc.subject | ANTIGEN PRESENTATION | - |
dc.subject | MULTIPLE DEFECTS | - |
dc.subject | SELF-ANTIGENS | - |
dc.subject | LIPID ANTIGEN | - |
dc.subject | RECOGNITION | - |
dc.title | The effect of intracellular trafficking of CD1d on the formation of TCR repertoire of NKT cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Jung Hoon | - |
dc.contributor.affiliatedAuthor | Park, Se-Ho | - |
dc.identifier.doi | 10.5483/BMBRep.2014.47.5.077 | - |
dc.identifier.wosid | 000336835300001 | - |
dc.identifier.bibliographicCitation | BMB REPORTS, v.47, no.5, pp.241 - 248 | - |
dc.relation.isPartOf | BMB REPORTS | - |
dc.citation.title | BMB REPORTS | - |
dc.citation.volume | 47 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 241 | - |
dc.citation.endPage | 248 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.identifier.kciid | ART001877234 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | KILLER T-CELLS | - |
dc.subject.keywordPlus | C-GLYCOSIDE ANALOG | - |
dc.subject.keywordPlus | LIGAND ALPHA-GALACTOSYLCERAMIDE | - |
dc.subject.keywordPlus | TRIGLYCERIDE TRANSFER PROTEIN | - |
dc.subject.keywordPlus | CLASS-II MOLECULES | - |
dc.subject.keywordPlus | ANTIGEN PRESENTATION | - |
dc.subject.keywordPlus | MULTIPLE DEFECTS | - |
dc.subject.keywordPlus | SELF-ANTIGENS | - |
dc.subject.keywordPlus | LIPID ANTIGEN | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordAuthor | Antigen presentation | - |
dc.subject.keywordAuthor | CD1d | - |
dc.subject.keywordAuthor | Endosome | - |
dc.subject.keywordAuthor | Endolysosomal compartment | - |
dc.subject.keywordAuthor | Glycolipid | - |
dc.subject.keywordAuthor | Lysosome | - |
dc.subject.keywordAuthor | NKT cells | - |
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