The effect of intracellular trafficking of CD1d on the formation of TCR repertoire of NKT cells
- Authors
- Shin, Jung Hoon; Park, Se-Ho
- Issue Date
- 31-5월-2014
- Publisher
- KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
- Keywords
- Antigen presentation; CD1d; Endosome; Endolysosomal compartment; Glycolipid; Lysosome; NKT cells
- Citation
- BMB REPORTS, v.47, no.5, pp.241 - 248
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- BMB REPORTS
- Volume
- 47
- Number
- 5
- Start Page
- 241
- End Page
- 248
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/98481
- DOI
- 10.5483/BMBRep.2014.47.5.077
- ISSN
- 1976-6696
- Abstract
- CD1 molecules belong to non-polymorphic MHC class I-like proteins and present lipid antigens to T cells. Five different CD1 genes (CD1a-e) have been identified and classified into two groups. Group 1 include CD1a-c and present pathogenic lipid antigens to alpha beta T cells reminiscence of peptide antigen presentation by MHC-I molecules. CD1d is the only member of Group 2 and presents foreign and self lipid antigens to a specialized subset of alpha beta T cells, NKT cells. NKT cells are involved in diverse immune responses through prompt and massive production of cytokines. CD1d-dependent NKT cells are categorized upon the usage of their T cell receptors. A major subtype of NKT cells (type I) is invariant NKT cells which utilize invariant V alpha 14-J alpha 18 TCR alpha chain in mouse. The remaining NKT cells (type II) utilize diverse TCR alpha chains. Engineered CD1d molecules with modified intracellular trafficking produce either type I or type II NKT cell-defects suggesting the lipid antigens for each subtypes of NKT cells are processed/generated in different intracellular compartments. Since the usage of TCR by a T cell is the result of antigen-driven selection, the intracellular metabolic pathways of lipid antigen are a key in forming the functional NKT cell repertoire.
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Collections - College of Life Sciences and Biotechnology > Division of Life Sciences > 1. Journal Articles
- Graduate School > Department of Life Sciences > 1. Journal Articles
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