Optimization of pancreatic lipase inhibition by Cudrania tricuspidata fruits using response surface methodology
DC Field | Value | Language |
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dc.contributor.author | Jeong, Ji Yeon | - |
dc.contributor.author | Jo, Yang Hee | - |
dc.contributor.author | Lee, Ki Yong | - |
dc.contributor.author | Do, Seon-Gil | - |
dc.contributor.author | Hwang, Bang Yeon | - |
dc.contributor.author | Lee, Mi Kyeong | - |
dc.date.accessioned | 2021-09-05T08:46:58Z | - |
dc.date.available | 2021-09-05T08:46:58Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-05-15 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/98506 | - |
dc.description.abstract | The fruits of Cudrania tricuspidata (Carr.) Bur. (Moraceae) significantly inhibited pancreatic lipase, which plays a key role in fat absorption. Optimization of extraction conditions with minimum pancreatic lipase activity and maximum yield was determined using response surface methodology with three-level-three-factor Box-Behnken design (BBD). Regression analysis showed a good fit of the experimental data and the optimal condition was obtained as ethanol concentration, 74.5%; temperature 61.9 degrees C and extraction time, 13.5 h. The pancreatic lipase activity and extraction yield under optimal conditions were found to be 65.5% and 54.0%, respectively, which were well matched with the predicted value of 65.8% and 47.1%. Further fractionation of C. tricuspidata extract resulted in the isolation of compound 1, which was identified as 5,7,4'-trihydroxy-6,8-diprenylisoflavone. It inhibited pancreatic lipase activity with IC50 value of 65.0 mu M. HPLC analysis suggested positive correlation between pancreatic lipase inhibition and 5,7,4 '-trihydroxy-6,8-diprenylisoflavone of C. tricuspidata fruits. (C) 2014 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | EXTRACTION | - |
dc.subject | FLAVONOIDS | - |
dc.subject | OBESITY | - |
dc.title | Optimization of pancreatic lipase inhibition by Cudrania tricuspidata fruits using response surface methodology | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Ki Yong | - |
dc.identifier.doi | 10.1016/j.bmcl.2014.03.067 | - |
dc.identifier.scopusid | 2-s2.0-84899623355 | - |
dc.identifier.wosid | 000335517300020 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.24, no.10, pp.2329 - 2333 | - |
dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.volume | 24 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2329 | - |
dc.citation.endPage | 2333 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.subject.keywordPlus | EXTRACTION | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordAuthor | Cudrania tricuspidata | - |
dc.subject.keywordAuthor | Response surface methodology | - |
dc.subject.keywordAuthor | Box-Behnken design | - |
dc.subject.keywordAuthor | Pancreatic lipase | - |
dc.subject.keywordAuthor | 5,7,4 &apos | - |
dc.subject.keywordAuthor | -Trihydroxy-6,8-diprenylisoflavone | - |
dc.subject.keywordAuthor | Optimization | - |
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