Detailed Information
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
Structural characterization of P1 '-diversified urea-based inhibitors of glutamate carboxypeptidase II
- Authors
- Pavlicek, Jiri; Ptacek, Jakub; Cerny, Jiri; Byun, Youngjoo; Skultetyova, Lubica; Pomper, Martin G.; Lubkowski, Jacek; Barinka, Cyril
- Issue Date
- 15-May-2014
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- GCPII; Prostate-specific membrane antigen; PSMA; Metallopeptidase; X-ray crystallography; Structure-based drug design; Urea-based inhibitor
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.24, no.10, pp.2340 - 2345
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 24
- Number
- 10
- Start Page
- 2340
- End Page
- 2345
- ISSN
- 0960-894X
- Abstract
- Urea-based inhibitors of human glutamate carboxypeptidase II (GCPII) have advanced into clinical trials for imaging metastatic prostate cancer. In parallel efforts, agents with increased lipophilicity have been designed and evaluated for targeting GCPII residing within the neuraxis. Here we report the structural and computational characterization of six complexes between GCPII and P1 '-diversified urea-based inhibitors that have the C-terminal glutamate replaced by more hydrophobic moieties. The X-ray structures are complemented by quantum mechanics calculations that provide a quantitative insight into the GCPII/inhibitor interactions. These data can be used for the rational design of novel glutamate-free GCPII inhibitors with tailored physicochemical properties. (C) 2014 Elsevier Ltd. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Pharmacy > Department of Pharmaceutical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Related Researcher
- Byun, Young joo
- College of Pharmacy (Department of Pharmaceutical Science)