COMT Val158Met and PPAR gamma Pro12Ala polymorphisms and susceptibility to Alzheimer's disease: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.date.accessioned | 2021-09-05T09:04:15Z | - |
dc.date.available | 2021-09-05T09:04:15Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-05 | - |
dc.identifier.issn | 1590-1874 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/98591 | - |
dc.description.abstract | The aim of this study was to explore whether the catechol-O-methyltransferase (COMT) Val158Met or the peroxisome proliferator-activated receptor-gamma (PPAR gamma) Pro12Ala polymorphisms are associated with susceptibility to Alzheimer's disease (AD). We conducted a meta-analysis of the associations between the COMT Val158Met and the PPAR gamma Pro12Ala polymorphisms and AD in subjects. Meta-analysis showed no association between AD and the COMT G allele in any of the study subjects [ odds ratio (OR) = 0.972, 95 % confidence intervals (95 % CI) = 0.893-1.059, p = 0.515]. Stratification by ethnicity indicated an association between the COMT GG+GA genotype and AD in an Asian group (OR = 0.702, 95 % CI = 0.517-0.953, p = 0.023), but not in Europeans (OR = 1.058, 95 % CI = 0.868-1.289, p = 0.579). Homozygote contrast analysis showed the same pattern for the COMT GG+GA genotype. Meta-analysis showed no association between AD and the PPAR gamma polymorphism (OR for the C allele = 0.963, 95 % CI = 0.818-1.134, p = 0.649). This meta-analysis identified an association between AD and the COMT Val158Met polymorphism in Asians but not in Europeans, but it revealed no association between AD and the PPAR gamma Pro12Ala polymorphism. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER-VERLAG ITALIA SRL | - |
dc.subject | ACTIVATED RECEPTOR-GAMMA | - |
dc.subject | CATECHOL-O-METHYLTRANSFERASE | - |
dc.subject | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject | ASSOCIATION ANALYSIS | - |
dc.subject | PARKINSONS-DISEASE | - |
dc.subject | GENE POLYMORPHISMS | - |
dc.subject | RISK | - |
dc.subject | ONSET | - |
dc.title | COMT Val158Met and PPAR gamma Pro12Ala polymorphisms and susceptibility to Alzheimer's disease: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.identifier.doi | 10.1007/s10072-014-1645-4 | - |
dc.identifier.scopusid | 2-s2.0-84901347534 | - |
dc.identifier.wosid | 000336810100001 | - |
dc.identifier.bibliographicCitation | NEUROLOGICAL SCIENCES, v.35, no.5, pp.643 - 651 | - |
dc.relation.isPartOf | NEUROLOGICAL SCIENCES | - |
dc.citation.title | NEUROLOGICAL SCIENCES | - |
dc.citation.volume | 35 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 643 | - |
dc.citation.endPage | 651 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | ACTIVATED RECEPTOR-GAMMA | - |
dc.subject.keywordPlus | CATECHOL-O-METHYLTRANSFERASE | - |
dc.subject.keywordPlus | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject.keywordPlus | ASSOCIATION ANALYSIS | - |
dc.subject.keywordPlus | PARKINSONS-DISEASE | - |
dc.subject.keywordPlus | GENE POLYMORPHISMS | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | ONSET | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | COMT | - |
dc.subject.keywordAuthor | PPAR gamma | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Meta-analysis | - |
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