COMT Val158Met and PPAR gamma Pro12Ala polymorphisms and susceptibility to Alzheimer's disease: a meta-analysis
- Authors
- Lee, Young Ho; Song, Gwan Gyu
- Issue Date
- 5월-2014
- Publisher
- SPRINGER-VERLAG ITALIA SRL
- Keywords
- Alzheimer' s disease; COMT; PPAR gamma; Polymorphism; Meta-analysis
- Citation
- NEUROLOGICAL SCIENCES, v.35, no.5, pp.643 - 651
- Indexed
- SCIE
SCOPUS
- Journal Title
- NEUROLOGICAL SCIENCES
- Volume
- 35
- Number
- 5
- Start Page
- 643
- End Page
- 651
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/98591
- DOI
- 10.1007/s10072-014-1645-4
- ISSN
- 1590-1874
- Abstract
- The aim of this study was to explore whether the catechol-O-methyltransferase (COMT) Val158Met or the peroxisome proliferator-activated receptor-gamma (PPAR gamma) Pro12Ala polymorphisms are associated with susceptibility to Alzheimer's disease (AD). We conducted a meta-analysis of the associations between the COMT Val158Met and the PPAR gamma Pro12Ala polymorphisms and AD in subjects. Meta-analysis showed no association between AD and the COMT G allele in any of the study subjects [ odds ratio (OR) = 0.972, 95 % confidence intervals (95 % CI) = 0.893-1.059, p = 0.515]. Stratification by ethnicity indicated an association between the COMT GG+GA genotype and AD in an Asian group (OR = 0.702, 95 % CI = 0.517-0.953, p = 0.023), but not in Europeans (OR = 1.058, 95 % CI = 0.868-1.289, p = 0.579). Homozygote contrast analysis showed the same pattern for the COMT GG+GA genotype. Meta-analysis showed no association between AD and the PPAR gamma polymorphism (OR for the C allele = 0.963, 95 % CI = 0.818-1.134, p = 0.649). This meta-analysis identified an association between AD and the COMT Val158Met polymorphism in Asians but not in Europeans, but it revealed no association between AD and the PPAR gamma Pro12Ala polymorphism.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.