Serotype distribution and antibiotic resistance of Streptococcus pneumoniae isolated from invasive infections after optional use of the 7-valent conjugate vaccine in Korea, 2006-2010
- Authors
- Cho, Eun Young; Lee, Hyunju; Choi, Eun Hwa; Kim, Yae-Jean; Eun, Byung Wook; Cho, Yong Kyun; Kim, Yun-Kyung; Jo, Dae Sun; Lee, Hye Soo; Lee, Jina; Kim, Mi-Na; Kim, Dong Soo; Lee, Hoan Jong
- Issue Date
- 4월-2014
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Streptococcus pneumoniae; Serotype; Antimicrobial resistance; Pneumococcal vaccines
- Citation
- DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, v.78, no.4, pp.481 - 486
- Indexed
- SCIE
SCOPUS
- Journal Title
- DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
- Volume
- 78
- Number
- 4
- Start Page
- 481
- End Page
- 486
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/98848
- DOI
- 10.1016/j.diagmicrobio.2013.12.016
- ISSN
- 0732-8893
- Abstract
- This study examined the serotype distribution and antimicrobial resistance of pneumococcal isolates from invasive infections in children between 2006 and 2010, when the 7-valent pneumococcal conjugate vaccine (PCV7) was offered as an optional vaccine in Korea. Among 140 isolates collected from 8 centers, the common serotypes were 19A (22.9%), 19 F (12.1%), and 6B (8.6%). Between 2006 and 2010, PCV7 serotypes decreased from 62.5% to 21.4% (P = 0.002), whereas three 13-valent pneumococcal conjugate vaccine (PCV13)-specific serotypes (3, 6A, and 19A) increased from 18.8% to 42.9% (P = 0.016). Among 102 multidrug-resistant isolates, the proportion of PCV7 serotypes decreased from 65.2% to 21.7% (P = 0.001), and 3 PCV13-specific serotypes increased from 17.4% to 47.8% (P = 0.008). Optional PCV7 vaccination has influenced the proportion of PCV7 serotypes in Korea, resulting in a decrease, whereas the proportions of 3 PCV13-specific serotypes, particularly 19A, have increased. (C) 2014 Elsevier Inc. All rights reserved.
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