Loss of CDC14B Expression in Clear Cell Renal Cell Carcinoma Meta-Analysis of Microarray Data Sets
- Authors
- Kim, Younghye; Choi, Jung-Woo; Lee, Ju-Han; Kim, Young-Sik
- Issue Date
- 4월-2014
- Publisher
- OXFORD UNIV PRESS INC
- Keywords
- Renal cell carcinoma; Mete-analysis; Microarray; CDC14B
- Citation
- AMERICAN JOURNAL OF CLINICAL PATHOLOGY, v.141, no.4, pp.551 - 558
- Indexed
- SCIE
SCOPUS
- Journal Title
- AMERICAN JOURNAL OF CLINICAL PATHOLOGY
- Volume
- 141
- Number
- 4
- Start Page
- 551
- End Page
- 558
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/98882
- DOI
- 10.1309/AJCP4PE4JPSRGBQS
- ISSN
- 0002-9173
- Abstract
- Objectives: To discover significant differentially expressed genes (DEGs) in clear cell renal cell carcinoma (ccRCC) that might be unidentified by single microarray analysis. Methods: The effect sizes of five ccRCC microarray data sets were combined using a random-effects model. The most downregulated gene was validated in paired 80 ccRCC tissues by immunohistochemistry. Results: CDC14B was the most downregulated gene among 1,761 DEGs. CDC14B was strongly expressed in the apical proximal tubules in the nonneoplastic tissues, while it was completely absent in 10 (12.5%) of 80 or downregulated in 70 (87.5%) of 80 ccRCC cases. The complete loss of CDC14B correlated with high T stage (P = .038), advanced TNM stage (P = .027), tumor recurrence (P = .038), and shorter recurrence-free survival (P = .046) compared with the partial loss of CDC14B. Conclusions: Microarray meta-analysis is a useful tool for pathologists. CDC14B expression is downregulated in ccRCC, suggesting its role in renal carcinogenesis.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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