Anti-inflammatory activity of a methanol extract from Ardisia tinctoria on mouse macrophages and paw edema
DC Field | Value | Language |
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dc.contributor.author | Kim, Hui-Seong | - |
dc.contributor.author | Park, Ji-Won | - |
dc.contributor.author | Kwon, Ok-Kyoung | - |
dc.contributor.author | Kim, Jea-Hong | - |
dc.contributor.author | Oh, Sei-Ryang | - |
dc.contributor.author | Lee, Hyeong-Kyu | - |
dc.contributor.author | Tran The Bach | - |
dc.contributor.author | Bui Hong Quang | - |
dc.contributor.author | Ahn, Kyung-Seop | - |
dc.date.accessioned | 2021-09-05T10:20:08Z | - |
dc.date.available | 2021-09-05T10:20:08Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-04 | - |
dc.identifier.issn | 1791-2997 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/98956 | - |
dc.description.abstract | Ardisia tinctoria (AT) is a plant of the Myrsinaceae family. No studies on its anti-inflammatory effects have yet been reported. This study investigated the anti-inflammatory activity of AT. A non-cytotoxic methanol extract of AT inhibited the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), leading to significantly reduced levels of nitric oxide (NO) and prostaglandin E-2 (PGE(2)) and of two proteins regulated by these, interleukin-1 beta (IL-1 beta) and IL-6, in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. The thickness of paw edema induced in vivo in mice by carrageenan administration was effectively reduced by the AT extract. Translocation of the nuclear factor-kappa B (NF-kappa B) subunit 65 (p65) into the nucleus and phosphorylation of mitogen-activated protein kinase kinase (MEK) and extracellular signal-related kinase (ERK) were inhibited by the AT extract. Our results indicated that a methanol extract of AT downregulates the inflammatory response by blocking phosphorylation of MEK and ERK and activation of NF-kappa B. To the best of our knowledge, this is the first study of anti-inflammatory effects of an AT extract, and demonstrates its potential in the treatment of inflammatory diseases. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | NITRIC-OXIDE SYNTHASE | - |
dc.subject | ACTIVATION | - |
dc.subject | INFLAMMATION | - |
dc.subject | INDUCTION | - |
dc.subject | LIPOPOLYSACCHARIDE | - |
dc.subject | EXPRESSION | - |
dc.subject | MECHANISMS | - |
dc.subject | KINASE | - |
dc.subject | CELLS | - |
dc.title | Anti-inflammatory activity of a methanol extract from Ardisia tinctoria on mouse macrophages and paw edema | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jea-Hong | - |
dc.identifier.doi | 10.3892/mmr.2014.1941 | - |
dc.identifier.scopusid | 2-s2.0-84896520036 | - |
dc.identifier.wosid | 000334345300048 | - |
dc.identifier.bibliographicCitation | MOLECULAR MEDICINE REPORTS, v.9, no.4, pp.1388 - 1394 | - |
dc.relation.isPartOf | MOLECULAR MEDICINE REPORTS | - |
dc.citation.title | MOLECULAR MEDICINE REPORTS | - |
dc.citation.volume | 9 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1388 | - |
dc.citation.endPage | 1394 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | Ardisia tinctoria | - |
dc.subject.keywordAuthor | MAPK | - |
dc.subject.keywordAuthor | nitric oxid | - |
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