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Anti-inflammatory activity of a methanol extract from Ardisia tinctoria on mouse macrophages and paw edema

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dc.contributor.authorKim, Hui-Seong-
dc.contributor.authorPark, Ji-Won-
dc.contributor.authorKwon, Ok-Kyoung-
dc.contributor.authorKim, Jea-Hong-
dc.contributor.authorOh, Sei-Ryang-
dc.contributor.authorLee, Hyeong-Kyu-
dc.contributor.authorTran The Bach-
dc.contributor.authorBui Hong Quang-
dc.contributor.authorAhn, Kyung-Seop-
dc.date.accessioned2021-09-05T10:20:08Z-
dc.date.available2021-09-05T10:20:08Z-
dc.date.created2021-06-15-
dc.date.issued2014-04-
dc.identifier.issn1791-2997-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/98956-
dc.description.abstractArdisia tinctoria (AT) is a plant of the Myrsinaceae family. No studies on its anti-inflammatory effects have yet been reported. This study investigated the anti-inflammatory activity of AT. A non-cytotoxic methanol extract of AT inhibited the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), leading to significantly reduced levels of nitric oxide (NO) and prostaglandin E-2 (PGE(2)) and of two proteins regulated by these, interleukin-1 beta (IL-1 beta) and IL-6, in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. The thickness of paw edema induced in vivo in mice by carrageenan administration was effectively reduced by the AT extract. Translocation of the nuclear factor-kappa B (NF-kappa B) subunit 65 (p65) into the nucleus and phosphorylation of mitogen-activated protein kinase kinase (MEK) and extracellular signal-related kinase (ERK) were inhibited by the AT extract. Our results indicated that a methanol extract of AT downregulates the inflammatory response by blocking phosphorylation of MEK and ERK and activation of NF-kappa B. To the best of our knowledge, this is the first study of anti-inflammatory effects of an AT extract, and demonstrates its potential in the treatment of inflammatory diseases.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherSPANDIDOS PUBL LTD-
dc.subjectNF-KAPPA-B-
dc.subjectNITRIC-OXIDE SYNTHASE-
dc.subjectACTIVATION-
dc.subjectINFLAMMATION-
dc.subjectINDUCTION-
dc.subjectLIPOPOLYSACCHARIDE-
dc.subjectEXPRESSION-
dc.subjectMECHANISMS-
dc.subjectKINASE-
dc.subjectCELLS-
dc.titleAnti-inflammatory activity of a methanol extract from Ardisia tinctoria on mouse macrophages and paw edema-
dc.typeArticle-
dc.contributor.affiliatedAuthorKim, Jea-Hong-
dc.identifier.doi10.3892/mmr.2014.1941-
dc.identifier.scopusid2-s2.0-84896520036-
dc.identifier.wosid000334345300048-
dc.identifier.bibliographicCitationMOLECULAR MEDICINE REPORTS, v.9, no.4, pp.1388 - 1394-
dc.relation.isPartOfMOLECULAR MEDICINE REPORTS-
dc.citation.titleMOLECULAR MEDICINE REPORTS-
dc.citation.volume9-
dc.citation.number4-
dc.citation.startPage1388-
dc.citation.endPage1394-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaOncology-
dc.relation.journalResearchAreaResearch & Experimental Medicine-
dc.relation.journalWebOfScienceCategoryOncology-
dc.relation.journalWebOfScienceCategoryMedicine, Research & Experimental-
dc.subject.keywordPlusNF-KAPPA-B-
dc.subject.keywordPlusNITRIC-OXIDE SYNTHASE-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusINFLAMMATION-
dc.subject.keywordPlusINDUCTION-
dc.subject.keywordPlusLIPOPOLYSACCHARIDE-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusMECHANISMS-
dc.subject.keywordPlusKINASE-
dc.subject.keywordPlusCELLS-
dc.subject.keywordAuthorNF-kappa B-
dc.subject.keywordAuthorinflammation-
dc.subject.keywordAuthorArdisia tinctoria-
dc.subject.keywordAuthorMAPK-
dc.subject.keywordAuthornitric oxid-
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