Anti-inflammatory activity of a methanol extract from Ardisia tinctoria on mouse macrophages and paw edema
- Authors
- Kim, Hui-Seong; Park, Ji-Won; Kwon, Ok-Kyoung; Kim, Jea-Hong; Oh, Sei-Ryang; Lee, Hyeong-Kyu; Tran The Bach; Bui Hong Quang; Ahn, Kyung-Seop
- Issue Date
- 4월-2014
- Publisher
- SPANDIDOS PUBL LTD
- Keywords
- NF-kappa B; inflammation; Ardisia tinctoria; MAPK; nitric oxid
- Citation
- MOLECULAR MEDICINE REPORTS, v.9, no.4, pp.1388 - 1394
- Indexed
- SCIE
SCOPUS
- Journal Title
- MOLECULAR MEDICINE REPORTS
- Volume
- 9
- Number
- 4
- Start Page
- 1388
- End Page
- 1394
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/98956
- DOI
- 10.3892/mmr.2014.1941
- ISSN
- 1791-2997
- Abstract
- Ardisia tinctoria (AT) is a plant of the Myrsinaceae family. No studies on its anti-inflammatory effects have yet been reported. This study investigated the anti-inflammatory activity of AT. A non-cytotoxic methanol extract of AT inhibited the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), leading to significantly reduced levels of nitric oxide (NO) and prostaglandin E-2 (PGE(2)) and of two proteins regulated by these, interleukin-1 beta (IL-1 beta) and IL-6, in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. The thickness of paw edema induced in vivo in mice by carrageenan administration was effectively reduced by the AT extract. Translocation of the nuclear factor-kappa B (NF-kappa B) subunit 65 (p65) into the nucleus and phosphorylation of mitogen-activated protein kinase kinase (MEK) and extracellular signal-related kinase (ERK) were inhibited by the AT extract. Our results indicated that a methanol extract of AT downregulates the inflammatory response by blocking phosphorylation of MEK and ERK and activation of NF-kappa B. To the best of our knowledge, this is the first study of anti-inflammatory effects of an AT extract, and demonstrates its potential in the treatment of inflammatory diseases.
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