Oxidative stress level is not associated with survival in terminally ill cancer patients: a preliminary study
- Authors
- Yeom, Chang Hwan; Choi, Youn Seon; Ahn, Hong Yup; Lee, Su Hey; Hwang, In Cheol
- Issue Date
- 21-3월-2014
- Publisher
- BIOMED CENTRAL LTD
- Keywords
- Quality of life; Survival; EORTC QLQ-C15-PAL; Performance status; Palliative care
- Citation
- BMC PALLIATIVE CARE, v.13
- Indexed
- SCIE
SSCI
SCOPUS
- Journal Title
- BMC PALLIATIVE CARE
- Volume
- 13
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/98992
- DOI
- 10.1186/1472-684X-13-14
- ISSN
- 1472-684X
- Abstract
- Background: While cancer patients have higher oxidative stress (OS) and lower antioxidant activity, evidence for the association of these parameters with survival in patients with terminally ill cancer is lacking. Methods: We followed 65 terminal cancer patients prospectively. We assessed their performance status, some symptoms, and serum levels of vitamin C and OS level. The Gehan's generalized Wilcoxon test was used to examine the association between survival times and variables. Results: Subjects' performance status was very poor and they had a high level of OS and a low level of vitamin C. No significant association of these two parameters with survival time was noted (p-value, 0.637 for high OS and 0.240 for low vitamin C). Poor performance status was independently related to high OS status after adjusting for potential confounders (adjusted OR, 4.45; p-value, 0.031). Conclusions: In this study, OS was not associated with survival of terminally ill cancer patients and its prognostic role requires further study.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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