Effects of electroacupuncture on oxaliplatin-induced neuropathic cold hypersensitivity in rats
DC Field | Value | Language |
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dc.contributor.author | Moon, Hak Jin | - |
dc.contributor.author | Lim, Bong-Soo | - |
dc.contributor.author | Lee, Dae-Il | - |
dc.contributor.author | Ye, Min Sook | - |
dc.contributor.author | Lee, Giseog | - |
dc.contributor.author | Min, Byung-Il | - |
dc.contributor.author | Bae, Hyunsu | - |
dc.contributor.author | Na, Heung Sik | - |
dc.contributor.author | Kim, Sun Kwang | - |
dc.date.accessioned | 2021-09-05T11:12:42Z | - |
dc.date.available | 2021-09-05T11:12:42Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-03 | - |
dc.identifier.issn | 1880-6546 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/99220 | - |
dc.description.abstract | This study investigated whether and how electroacupuncture (EA) attenuates cold hypersensitivity (allodynia) in a rat model of oxaliplatin-induced neuropathic pain. Cold allodynia [evaluated by immersing the tail into cold water (4 A degrees C) and measuring the withdrawal latency] was induced 3 days after an oxaliplatin administration (6 mg/kg, i.p.). EA stimulation (2/100 Hz, 0.3-ms pulse duration, 0.2-0.3 mA) was delivered to ST36 acupoint or non-acupoint for 20 min. Low-frequency (2 Hz) EA at ST36 relieved cold allodynia more effectively than high-frequency EA at ST36 or low-frequency EA at non-acupoint. Naloxone (opioid antagonist, 2 mg/kg, i.p.) completely blocked such EA-induced anti-allodynia, whereas phentolamine (alpha-adrenergic antagonist, 2 mg/kg, i.p.) did not. Moreover, plasma beta-endorphin levels significantly increased right after the end of EA and subsequently decreased. These results indicate that low-frequency EA at ST36 in rats has a marked relieving effect on oxaliplatin-induced cold allodynia that is mediated by the endogenous opioid, but not noradrenergic, system. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER JAPAN KK | - |
dc.subject | ANKLE SPRAIN PAIN | - |
dc.subject | CAUDAL TRUNK INJURY | - |
dc.subject | ACUPUNCTURE ANALGESIA | - |
dc.subject | MECHANICAL ALLODYNIA | - |
dc.subject | OPIOID RECEPTORS | - |
dc.subject | LONG-TERM | - |
dc.subject | MODEL | - |
dc.subject | NEUROTOXICITY | - |
dc.subject | HYPERALGESIA | - |
dc.subject | EXPRESSION | - |
dc.title | Effects of electroacupuncture on oxaliplatin-induced neuropathic cold hypersensitivity in rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Na, Heung Sik | - |
dc.identifier.doi | 10.1007/s12576-013-0297-0 | - |
dc.identifier.scopusid | 2-s2.0-84895827497 | - |
dc.identifier.wosid | 000331966200008 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PHYSIOLOGICAL SCIENCES, v.64, no.2, pp.151 - 156 | - |
dc.relation.isPartOf | JOURNAL OF PHYSIOLOGICAL SCIENCES | - |
dc.citation.title | JOURNAL OF PHYSIOLOGICAL SCIENCES | - |
dc.citation.volume | 64 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 151 | - |
dc.citation.endPage | 156 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.subject.keywordPlus | ANKLE SPRAIN PAIN | - |
dc.subject.keywordPlus | CAUDAL TRUNK INJURY | - |
dc.subject.keywordPlus | ACUPUNCTURE ANALGESIA | - |
dc.subject.keywordPlus | MECHANICAL ALLODYNIA | - |
dc.subject.keywordPlus | OPIOID RECEPTORS | - |
dc.subject.keywordPlus | LONG-TERM | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | NEUROTOXICITY | - |
dc.subject.keywordPlus | HYPERALGESIA | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | Oxaliplatin | - |
dc.subject.keywordAuthor | Cold allodynia | - |
dc.subject.keywordAuthor | Electroacupuncture | - |
dc.subject.keywordAuthor | Endogenous opioid | - |
dc.subject.keywordAuthor | Noradrenergic | - |
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