Effects of electroacupuncture on oxaliplatin-induced neuropathic cold hypersensitivity in rats
- Authors
- Moon, Hak Jin; Lim, Bong-Soo; Lee, Dae-Il; Ye, Min Sook; Lee, Giseog; Min, Byung-Il; Bae, Hyunsu; Na, Heung Sik; Kim, Sun Kwang
- Issue Date
- 3월-2014
- Publisher
- SPRINGER JAPAN KK
- Keywords
- Oxaliplatin; Cold allodynia; Electroacupuncture; Endogenous opioid; Noradrenergic
- Citation
- JOURNAL OF PHYSIOLOGICAL SCIENCES, v.64, no.2, pp.151 - 156
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF PHYSIOLOGICAL SCIENCES
- Volume
- 64
- Number
- 2
- Start Page
- 151
- End Page
- 156
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/99220
- DOI
- 10.1007/s12576-013-0297-0
- ISSN
- 1880-6546
- Abstract
- This study investigated whether and how electroacupuncture (EA) attenuates cold hypersensitivity (allodynia) in a rat model of oxaliplatin-induced neuropathic pain. Cold allodynia [evaluated by immersing the tail into cold water (4 A degrees C) and measuring the withdrawal latency] was induced 3 days after an oxaliplatin administration (6 mg/kg, i.p.). EA stimulation (2/100 Hz, 0.3-ms pulse duration, 0.2-0.3 mA) was delivered to ST36 acupoint or non-acupoint for 20 min. Low-frequency (2 Hz) EA at ST36 relieved cold allodynia more effectively than high-frequency EA at ST36 or low-frequency EA at non-acupoint. Naloxone (opioid antagonist, 2 mg/kg, i.p.) completely blocked such EA-induced anti-allodynia, whereas phentolamine (alpha-adrenergic antagonist, 2 mg/kg, i.p.) did not. Moreover, plasma beta-endorphin levels significantly increased right after the end of EA and subsequently decreased. These results indicate that low-frequency EA at ST36 in rats has a marked relieving effect on oxaliplatin-induced cold allodynia that is mediated by the endogenous opioid, but not noradrenergic, system.
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