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The prognostic significance of preoperative leukocytosis in epithelial ovarian carcinoma: A retrospective cohort study

Authors
So, Kyeong A.Hong, Jin HwaJin, Hye MiKim, Jae WonSong, Jae YunLee, Jae KwanLee, Nak Woo
Issue Date
3월-2014
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
Leukocytosis; Ovarian cancer; Recurrence-free survival; Overall survival
Citation
GYNECOLOGIC ONCOLOGY, v.132, no.3, pp.551 - 555
Indexed
SCIE
SCOPUS
Journal Title
GYNECOLOGIC ONCOLOGY
Volume
132
Number
3
Start Page
551
End Page
555
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/99226
DOI
10.1016/j.ygyno.2014.01.010
ISSN
0090-8258
Abstract
Objective. Preoperative leukocytosis is known to be a negative prognostic factor for several gynecologic malignancies, but its relationship with epithelial ovarian carcinoma (EOC) is unknown. We sought to evaluate the prognostic implications of preoperative leukocytosis for women with EOC. Methods. We retrospectively reviewed the medical records of patients who underwent primary debulking surgery and adjuvant platinum-based chemotherapy for EOC between January 1993 and October 2011. Associations between leukocytosis and recurrence-free survival (RFS) and overall survival (OS) were determined by univariate analyses. Multivariate Cox proportional hazards regression was used to identify independent prognostic factors for RFS and OS. Results. Of 155 women, 23 (14.8%) had leukocytosis and 132 (85.2%) did not have leukocytosis. RFS and OS were significantly shorter for women with leukocytosis than for women without leukocytosis (P = 0.009 and P < 0.0001, respectively). The mortality rate was also higher among women with leukocytosis (P < 0.0001). Multivariate analysis revealed that preoperative leukocytosis (hazard ratio [HR]: 2.15; 95% confidence interval [CI]: 1.55-4.41; P = 0.009), advanced stage (HR: 3.12; 95% CI: 1.44-6.75; P = 0.004), and optimal cytoreduction (HR: 0.38; 95% CI: 0.14-0.70; P = 0.031) were independent prognostic factors for RFS. Additionally, preoperative leukocytosis was independently associated with decreased OS (HR: 7.66; 95% CI: 2.78-21.16; P < 0.0001). Conclusions. Among women with EOC, preoperative leukocytosis might be an independent prognostic factor for RFS and OS. A larger-scaled, prospective study is needed to verify these results. (C) 2014 Elsevier Inc. All rights reserved.
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