Single-Walled Carbon Nanotubes Induce Cell Death and Transcription of TNF-alpha in Macrophages Without Affecting Nitric Oxide Production
DC Field | Value | Language |
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dc.contributor.author | Kim, Kyong Hoon | - |
dc.contributor.author | Yeon, Seung-min | - |
dc.contributor.author | Kim, Hyun Gyung | - |
dc.contributor.author | Lee, Hwanbum | - |
dc.contributor.author | Kim, Sun Kyung | - |
dc.contributor.author | Han, Seung Hyun | - |
dc.contributor.author | Min, Kyung-Jin | - |
dc.contributor.author | Byun, Youngjoo | - |
dc.contributor.author | Lee, Eun Hee | - |
dc.contributor.author | Lee, Kenneth Sung | - |
dc.contributor.author | Yuk, Soon Hong | - |
dc.contributor.author | Ha, Un-Hwan | - |
dc.contributor.author | Jung, Yong Woo | - |
dc.date.accessioned | 2021-09-05T11:53:38Z | - |
dc.date.available | 2021-09-05T11:53:38Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-02 | - |
dc.identifier.issn | 0360-3997 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/99446 | - |
dc.description.abstract | Single-walled carbon nanotubes (SWCNTs) are potent nanomaterials that have diverse shapes and features. The utilization of these molecules for drug delivery is being investigated; thus, it is important to determine whether they alter immune responses against pathogens. In this study, we show that macrophages treated with a mixture of lipopolysaccharide and SWCNTs produced normal levels of nitric oxide and inducible nitric oxide synthase mRNA. However, these treatments induced cell death, presumably via necrosis. In addition, treating cells with SWCNTs induced the expression of tumor necrosis factor-alpha mRNA, a potent pro-inflammatory cytokine. These results suggest that SWCNTs may influence immune responses, which could result in unexpected effects following their administration for the purpose of drug delivery. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER/PLENUM PUBLISHERS | - |
dc.subject | TOLL-LIKE RECEPTORS | - |
dc.subject | IN-VITRO TOXICITY | - |
dc.subject | VIRAL-INFECTION | - |
dc.subject | KAPPA-B | - |
dc.subject | NANOMATERIALS | - |
dc.subject | MICE | - |
dc.subject | ACTIVATION | - |
dc.subject | EXPRESSION | - |
dc.subject | MOLECULES | - |
dc.subject | ASBESTOS | - |
dc.title | Single-Walled Carbon Nanotubes Induce Cell Death and Transcription of TNF-alpha in Macrophages Without Affecting Nitric Oxide Production | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Byun, Youngjoo | - |
dc.contributor.affiliatedAuthor | Lee, Eun Hee | - |
dc.contributor.affiliatedAuthor | Yuk, Soon Hong | - |
dc.contributor.affiliatedAuthor | Ha, Un-Hwan | - |
dc.contributor.affiliatedAuthor | Jung, Yong Woo | - |
dc.identifier.doi | 10.1007/s10753-013-9710-3 | - |
dc.identifier.scopusid | 2-s2.0-84900375532 | - |
dc.identifier.wosid | 000330849600006 | - |
dc.identifier.bibliographicCitation | INFLAMMATION, v.37, no.1, pp.44 - 54 | - |
dc.relation.isPartOf | INFLAMMATION | - |
dc.citation.title | INFLAMMATION | - |
dc.citation.volume | 37 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 44 | - |
dc.citation.endPage | 54 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | TOLL-LIKE RECEPTORS | - |
dc.subject.keywordPlus | IN-VITRO TOXICITY | - |
dc.subject.keywordPlus | VIRAL-INFECTION | - |
dc.subject.keywordPlus | KAPPA-B | - |
dc.subject.keywordPlus | NANOMATERIALS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MOLECULES | - |
dc.subject.keywordPlus | ASBESTOS | - |
dc.subject.keywordAuthor | single-walled carbon nanotubes | - |
dc.subject.keywordAuthor | lipopolysaccharides | - |
dc.subject.keywordAuthor | macrophage | - |
dc.subject.keywordAuthor | cell death | - |
dc.subject.keywordAuthor | tumor necrosis factor-alpha | - |
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