Single-Walled Carbon Nanotubes Induce Cell Death and Transcription of TNF-alpha in Macrophages Without Affecting Nitric Oxide Production
- Authors
- Kim, Kyong Hoon; Yeon, Seung-min; Kim, Hyun Gyung; Lee, Hwanbum; Kim, Sun Kyung; Han, Seung Hyun; Min, Kyung-Jin; Byun, Youngjoo; Lee, Eun Hee; Lee, Kenneth Sung; Yuk, Soon Hong; Ha, Un-Hwan; Jung, Yong Woo
- Issue Date
- 2월-2014
- Publisher
- SPRINGER/PLENUM PUBLISHERS
- Keywords
- single-walled carbon nanotubes; lipopolysaccharides; macrophage; cell death; tumor necrosis factor-alpha
- Citation
- INFLAMMATION, v.37, no.1, pp.44 - 54
- Indexed
- SCIE
SCOPUS
- Journal Title
- INFLAMMATION
- Volume
- 37
- Number
- 1
- Start Page
- 44
- End Page
- 54
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/99446
- DOI
- 10.1007/s10753-013-9710-3
- ISSN
- 0360-3997
- Abstract
- Single-walled carbon nanotubes (SWCNTs) are potent nanomaterials that have diverse shapes and features. The utilization of these molecules for drug delivery is being investigated; thus, it is important to determine whether they alter immune responses against pathogens. In this study, we show that macrophages treated with a mixture of lipopolysaccharide and SWCNTs produced normal levels of nitric oxide and inducible nitric oxide synthase mRNA. However, these treatments induced cell death, presumably via necrosis. In addition, treating cells with SWCNTs induced the expression of tumor necrosis factor-alpha mRNA, a potent pro-inflammatory cytokine. These results suggest that SWCNTs may influence immune responses, which could result in unexpected effects following their administration for the purpose of drug delivery.
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- Appears in
Collections - College of Pharmacy > Department of Pharmaceutical Science > 1. Journal Articles
- Graduate School > Department of Biotechnology and Bioinformatics > 1. Journal Articles
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