Impaired Extinction of Learned Contextual Fear Memory in Early Growth Response 1 Knockout Mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Seungrie | - |
dc.contributor.author | Hong, Soontaek | - |
dc.contributor.author | Mo, Jiwon | - |
dc.contributor.author | Lee, Dongmin | - |
dc.contributor.author | Choi, Eunju | - |
dc.contributor.author | Choi, June-seek | - |
dc.contributor.author | Sun, Woong | - |
dc.contributor.author | Lee, Hyun Woo | - |
dc.contributor.author | Kim, Hyun | - |
dc.date.accessioned | 2021-09-05T12:00:46Z | - |
dc.date.available | 2021-09-05T12:00:46Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-01-31 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/99490 | - |
dc.description.abstract | Inductive expression of early growth response 1 (Egr-1) in neurons is associated with many forms of neuronal activity. However, only a few Egr-1 target genes are known in the brain. The results of this study demonstrate that Egr-1 knockout (KO) mice display impaired contextual extinction learning and normal fear acquisition relative to wild-type (WT) control animals. Genome-wide microarray experiments revealed 368 differentially expressed genes in the hippocampus of Egr-1 WT exposed to different phases of a fear conditioning paradigm compared to gene expression profiles in the hippocampus of KO mice. Some of genes, such as serotonin receptor 2C (Htr2c), neuropeptide B (Npb), neuronal PAS domain protein 4 (Npas4), NPY receptor Y1 (Npy1r), fatty acid binding protein 7 (Fabp7), and neuropeptide Y (Npy) are known to regulate processing of fearful memories, and promoter analyses demonstrated that several of these genes contained Egr-1 binding sites. This study provides a useful list of potential Egr-1 target genes which may be regulated during fear memory processing. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.subject | DEPENDENT GENE-EXPRESSION | - |
dc.subject | IMMEDIATE-EARLY GENES | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | GLUTAMATE RECEPTORS | - |
dc.subject | SYNAPTIC PLASTICITY | - |
dc.subject | MESSENGER-RNA | - |
dc.subject | HIPPOCAMPUS | - |
dc.subject | TRANSCRIPTION | - |
dc.subject | REQUIREMENT | - |
dc.subject | INVOLVEMENT | - |
dc.title | Impaired Extinction of Learned Contextual Fear Memory in Early Growth Response 1 Knockout Mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, June-seek | - |
dc.contributor.affiliatedAuthor | Sun, Woong | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Woo | - |
dc.contributor.affiliatedAuthor | Kim, Hyun | - |
dc.identifier.doi | 10.14348/molcells.2014.2206 | - |
dc.identifier.scopusid | 2-s2.0-84901427460 | - |
dc.identifier.wosid | 000342559100004 | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.37, no.1, pp.24 - 30 | - |
dc.relation.isPartOf | MOLECULES AND CELLS | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 37 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 24 | - |
dc.citation.endPage | 30 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001847546 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | DEPENDENT GENE-EXPRESSION | - |
dc.subject.keywordPlus | IMMEDIATE-EARLY GENES | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | GLUTAMATE RECEPTORS | - |
dc.subject.keywordPlus | SYNAPTIC PLASTICITY | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | HIPPOCAMPUS | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | REQUIREMENT | - |
dc.subject.keywordPlus | INVOLVEMENT | - |
dc.subject.keywordAuthor | contextual fear conditioning | - |
dc.subject.keywordAuthor | Egr-1 | - |
dc.subject.keywordAuthor | extinction | - |
dc.subject.keywordAuthor | hippocampus | - |
dc.subject.keywordAuthor | microarray | - |
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