Impaired Extinction of Learned Contextual Fear Memory in Early Growth Response 1 Knockout Mice
- Authors
- Han, Seungrie; Hong, Soontaek; Mo, Jiwon; Lee, Dongmin; Choi, Eunju; Choi, June-seek; Sun, Woong; Lee, Hyun Woo; Kim, Hyun
- Issue Date
- 31-1월-2014
- Publisher
- KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
- Keywords
- contextual fear conditioning; Egr-1; extinction; hippocampus; microarray
- Citation
- MOLECULES AND CELLS, v.37, no.1, pp.24 - 30
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- MOLECULES AND CELLS
- Volume
- 37
- Number
- 1
- Start Page
- 24
- End Page
- 30
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/99490
- DOI
- 10.14348/molcells.2014.2206
- ISSN
- 1016-8478
- Abstract
- Inductive expression of early growth response 1 (Egr-1) in neurons is associated with many forms of neuronal activity. However, only a few Egr-1 target genes are known in the brain. The results of this study demonstrate that Egr-1 knockout (KO) mice display impaired contextual extinction learning and normal fear acquisition relative to wild-type (WT) control animals. Genome-wide microarray experiments revealed 368 differentially expressed genes in the hippocampus of Egr-1 WT exposed to different phases of a fear conditioning paradigm compared to gene expression profiles in the hippocampus of KO mice. Some of genes, such as serotonin receptor 2C (Htr2c), neuropeptide B (Npb), neuronal PAS domain protein 4 (Npas4), NPY receptor Y1 (Npy1r), fatty acid binding protein 7 (Fabp7), and neuropeptide Y (Npy) are known to regulate processing of fearful memories, and promoter analyses demonstrated that several of these genes contained Egr-1 binding sites. This study provides a useful list of potential Egr-1 target genes which may be regulated during fear memory processing.
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Collections - School of Psychology > School of Psychology > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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