Comparison of Acarbose and Voglibose in Diabetes Patients Who Are Inadequately Controlled with Basal Insulin Treatment: Randomized, Parallel, Open-Label, Active-Controlled Study
DC Field | Value | Language |
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dc.contributor.author | Lee, Mi Young | - |
dc.contributor.author | Choi, Dong Seop | - |
dc.contributor.author | Lee, Moon Kyu | - |
dc.contributor.author | Lee, Hyoung Woo | - |
dc.contributor.author | Park, Tae Sun | - |
dc.contributor.author | Kim, Doo Man | - |
dc.contributor.author | Chung, Choon Hee | - |
dc.contributor.author | Kim, Duk Kyu | - |
dc.contributor.author | Kim, In Joo | - |
dc.contributor.author | Jang, Hak Chul | - |
dc.contributor.author | Park, Yong Soo | - |
dc.contributor.author | Kwon, Hyuk Sang | - |
dc.contributor.author | Lee, Seung Hun | - |
dc.contributor.author | Shin, Hee Kang | - |
dc.date.accessioned | 2021-09-05T12:55:42Z | - |
dc.date.available | 2021-09-05T12:55:42Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-01 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/99731 | - |
dc.description.abstract | We studied the efficacy and safety of acarbose in comparison with voglibose in type 2 diabetes patients whose blood glucose levels were inadequately controlled with basal insulin alone or in combination with metformin (or a sulfonylurea). This study was a 24-week prospective, open-label, randomized, active-controlled multi-center study. Participants were randomized to receive either acarbose (n= 59, 300 mg/day) or voglibose (n = 62, 0.9 mg/day). The mean HbA(1c) at week 24 was significantly decreased approximately 0.7% from baseline in both acarbose (from 8.43% +/- 0.71% to 7.71% +/- 0.93%) and voglibose groups (from 8.38% +/- 0.73% to 7.68% +/- 0.94%). The mean fasting plasma glucose level and self-monitoring of blood glucose data from 1 hr before and after each meal were significantly decreased at week 24 in comparison to baseline in both groups. The levels 1 hr after dinner at week 24 were significantly decreased in the acarbose group (from 233.54 +/- 69.38 to 176.80 +/- 46.63 mg/dL) compared with the voglibose group (from 224.18 +/- 70.07 to 193.01 +/- 55.39 mg/dL). In conclusion, both acarbose and voglibose are efficacious and safe in patients with type 2 diabetes who are inadequately controlled with basal insulin. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.subject | IMPAIRED GLUCOSE-TOLERANCE | - |
dc.subject | GLYCEMIC CONTROL | - |
dc.subject | POSTPRANDIAL HYPERGLYCEMIA | - |
dc.subject | CARDIOVASCULAR BENEFITS | - |
dc.subject | 24-WEEK MONOTHERAPY | - |
dc.subject | NIDDM PATIENTS | - |
dc.subject | WEIGHT-GAIN | - |
dc.subject | GLARGINE | - |
dc.subject | EFFICACY | - |
dc.subject | THERAPY | - |
dc.title | Comparison of Acarbose and Voglibose in Diabetes Patients Who Are Inadequately Controlled with Basal Insulin Treatment: Randomized, Parallel, Open-Label, Active-Controlled Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Dong Seop | - |
dc.identifier.doi | 10.3346/jkms.2014.29.1.90 | - |
dc.identifier.scopusid | 2-s2.0-84900812689 | - |
dc.identifier.wosid | 000330508600014 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.29, no.1, pp.90 - 97 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 29 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 90 | - |
dc.citation.endPage | 97 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001844603 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | IMPAIRED GLUCOSE-TOLERANCE | - |
dc.subject.keywordPlus | GLYCEMIC CONTROL | - |
dc.subject.keywordPlus | POSTPRANDIAL HYPERGLYCEMIA | - |
dc.subject.keywordPlus | CARDIOVASCULAR BENEFITS | - |
dc.subject.keywordPlus | 24-WEEK MONOTHERAPY | - |
dc.subject.keywordPlus | NIDDM PATIENTS | - |
dc.subject.keywordPlus | WEIGHT-GAIN | - |
dc.subject.keywordPlus | GLARGINE | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordAuthor | Diabetes Mellitus, Type 2 | - |
dc.subject.keywordAuthor | Acarbose | - |
dc.subject.keywordAuthor | Voglibose | - |
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