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Comparison of Acarbose and Voglibose in Diabetes Patients Who Are Inadequately Controlled with Basal Insulin Treatment: Randomized, Parallel, Open-Label, Active-Controlled Study

Authors
Lee, Mi YoungChoi, Dong SeopLee, Moon KyuLee, Hyoung WooPark, Tae SunKim, Doo ManChung, Choon HeeKim, Duk KyuKim, In JooJang, Hak ChulPark, Yong SooKwon, Hyuk SangLee, Seung HunShin, Hee Kang
Issue Date
1월-2014
Publisher
KOREAN ACAD MEDICAL SCIENCES
Keywords
Diabetes Mellitus, Type 2; Acarbose; Voglibose
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.29, no.1, pp.90 - 97
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
Volume
29
Number
1
Start Page
90
End Page
97
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/99731
DOI
10.3346/jkms.2014.29.1.90
ISSN
1011-8934
Abstract
We studied the efficacy and safety of acarbose in comparison with voglibose in type 2 diabetes patients whose blood glucose levels were inadequately controlled with basal insulin alone or in combination with metformin (or a sulfonylurea). This study was a 24-week prospective, open-label, randomized, active-controlled multi-center study. Participants were randomized to receive either acarbose (n= 59, 300 mg/day) or voglibose (n = 62, 0.9 mg/day). The mean HbA(1c) at week 24 was significantly decreased approximately 0.7% from baseline in both acarbose (from 8.43% +/- 0.71% to 7.71% +/- 0.93%) and voglibose groups (from 8.38% +/- 0.73% to 7.68% +/- 0.94%). The mean fasting plasma glucose level and self-monitoring of blood glucose data from 1 hr before and after each meal were significantly decreased at week 24 in comparison to baseline in both groups. The levels 1 hr after dinner at week 24 were significantly decreased in the acarbose group (from 233.54 +/- 69.38 to 176.80 +/- 46.63 mg/dL) compared with the voglibose group (from 224.18 +/- 70.07 to 193.01 +/- 55.39 mg/dL). In conclusion, both acarbose and voglibose are efficacious and safe in patients with type 2 diabetes who are inadequately controlled with basal insulin.
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