A novel Pseudomonas aeruginosa-derived effector cooperates with flagella to mediate the upregulation of interleukin 8 in human epithelial cells
DC Field | Value | Language |
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dc.contributor.author | Kim, Yong-Jae | - |
dc.contributor.author | Paek, Se-Hwan | - |
dc.contributor.author | Jin, Shouguang | - |
dc.contributor.author | Park, Beom Seok | - |
dc.contributor.author | Ha, Un-Hwan | - |
dc.date.accessioned | 2021-09-05T12:58:08Z | - |
dc.date.available | 2021-09-05T12:58:08Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2014-01 | - |
dc.identifier.issn | 0882-4010 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/99748 | - |
dc.description.abstract | Infection with Pseudomonas aeruginosa results in a massive accumulation of neutrophils in response to prolonged and sustained expression of inflammatory mediators. The major chemokine associated with this excessive neutrophil recruitment is IL-8, the accumulation of which is a hallmark of cornea and cystic fibrosis airway inflammation. To date, several P. aeruginosa-associated and extracellular factors required for the stimulation of IL-8 expression have been identified. Here, we report a novel effector molecule, nucleoside diphosphate kinase (Ndk), which increases the expression of IL-8 by translocating into host cells. The induction appears to be dependent on both the kinase activity of Ndk and an additional bacterial factor, flagellin, via an NF-kappa B signaling pathway. This study demonstrates the role of a novel effector, Ndk, which is capable of inducing prominent inflammatory chemokine IL-8 expression with the aid of flagellin during P. aeruginosa infection. (C) 2013 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | - |
dc.subject | NUCLEOSIDE-DIPHOSPHATE-KINASE | - |
dc.subject | INNATE IMMUNE-RESPONSE | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | INFECTION | - |
dc.subject | IL-8 | - |
dc.subject | SECRETION | - |
dc.subject | CYTOKINES | - |
dc.subject | SURVIVAL | - |
dc.title | A novel Pseudomonas aeruginosa-derived effector cooperates with flagella to mediate the upregulation of interleukin 8 in human epithelial cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Paek, Se-Hwan | - |
dc.contributor.affiliatedAuthor | Ha, Un-Hwan | - |
dc.identifier.doi | 10.1016/j.micpath.2013.12.001 | - |
dc.identifier.scopusid | 2-s2.0-84890946475 | - |
dc.identifier.wosid | 000331853700004 | - |
dc.identifier.bibliographicCitation | MICROBIAL PATHOGENESIS, v.66, pp.24 - 28 | - |
dc.relation.isPartOf | MICROBIAL PATHOGENESIS | - |
dc.citation.title | MICROBIAL PATHOGENESIS | - |
dc.citation.volume | 66 | - |
dc.citation.startPage | 24 | - |
dc.citation.endPage | 28 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | NUCLEOSIDE-DIPHOSPHATE-KINASE | - |
dc.subject.keywordPlus | INNATE IMMUNE-RESPONSE | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | IL-8 | - |
dc.subject.keywordPlus | SECRETION | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordAuthor | Epithelial cells | - |
dc.subject.keywordAuthor | IL-8 | - |
dc.subject.keywordAuthor | Pseudomonas aeruginosa | - |
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