A novel Pseudomonas aeruginosa-derived effector cooperates with flagella to mediate the upregulation of interleukin 8 in human epithelial cells
- Authors
- Kim, Yong-Jae; Paek, Se-Hwan; Jin, Shouguang; Park, Beom Seok; Ha, Un-Hwan
- Issue Date
- 1월-2014
- Publisher
- ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
- Keywords
- Epithelial cells; IL-8; Pseudomonas aeruginosa
- Citation
- MICROBIAL PATHOGENESIS, v.66, pp.24 - 28
- Indexed
- SCIE
SCOPUS
- Journal Title
- MICROBIAL PATHOGENESIS
- Volume
- 66
- Start Page
- 24
- End Page
- 28
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/99748
- DOI
- 10.1016/j.micpath.2013.12.001
- ISSN
- 0882-4010
- Abstract
- Infection with Pseudomonas aeruginosa results in a massive accumulation of neutrophils in response to prolonged and sustained expression of inflammatory mediators. The major chemokine associated with this excessive neutrophil recruitment is IL-8, the accumulation of which is a hallmark of cornea and cystic fibrosis airway inflammation. To date, several P. aeruginosa-associated and extracellular factors required for the stimulation of IL-8 expression have been identified. Here, we report a novel effector molecule, nucleoside diphosphate kinase (Ndk), which increases the expression of IL-8 by translocating into host cells. The induction appears to be dependent on both the kinase activity of Ndk and an additional bacterial factor, flagellin, via an NF-kappa B signaling pathway. This study demonstrates the role of a novel effector, Ndk, which is capable of inducing prominent inflammatory chemokine IL-8 expression with the aid of flagellin during P. aeruginosa infection. (C) 2013 Elsevier Ltd. All rights reserved.
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Collections - College of Science and Technology > Department of Biotechnology and Bioinformatics > 1. Journal Articles
- Graduate School > Department of Biotechnology and Bioinformatics > 1. Journal Articles
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