A Clinical Case of Scrub Typhus in the United States Forces Korea Patient with Eschar and Genetic Identification of Orientia tsutsugamushi Using Multiplex PCR-Based Next-Generation Sequencing

Cho, Seungchan; Allison, Jon C.; Park, Kkothanahreum; No, Jin Sun; Lee, Seung-Ho; Park, Kyungmin; Kim, Jongwoo; Klein, Terry A.; Kim, Heung-Chul; Kim, Won-Keun; Song, Jin-Won

doi:10.3390/pathogens10040424

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A Clinical Case of Scrub Typhus in the United States Forces Korea Patient with Eschar and Genetic Identification of Orientia tsutsugamushi Using Multiplex PCR-Based Next-Generation Sequencing

Cho, Seungchan;
Allison, Jon C.;
Park, Kkothanahreum;
No, Jin Sun;
Lee, Seung-Ho;
... Song, Jin-Won;
외 5명

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초록

An epidemiological investigation was conducted for a scrub typhus case reported in a U.S. Forces Korea military patient in the Republic of Korea in November 2018. The patient had a fever, maculopapular rash, and an eschar. The full-length sequence of Orientia tsutsugamushi 56-kDa type-specific antigen (TSA) gene was obtained from eschar tissue by multiplex PCR-based Next Generation Sequencing for genetic identification. Based on the 56-kDa TSA gene, the O. tsutsugamushi aligned most closely with the Boryong strain.

키워드

Orientia tsutsugamushi; scrub typhus; genetic identification; target enrichment next-generation sequencing

제목: A Clinical Case of Scrub Typhus in the United States Forces Korea Patient with Eschar and Genetic Identification of Orientia tsutsugamushi Using Multiplex PCR-Based Next-Generation Sequencing

저자: Cho, Seungchan; Allison, Jon C.; Park, Kkothanahreum; No, Jin Sun; Lee, Seung-Ho; Park, Kyungmin; Kim, Jongwoo; Klein, Terry A.; Kim, Heung-Chul; Kim, Won-Keun; Song, Jin-Won

DOI: 10.3390/pathogens10040424

발행일: 2021-04

유형: Article

저널명: Pathogens

권: 10

호: 4