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Detection of A beta plaques in mouse brain by using a disaggregation-induced fluorescence-enhancing probe
- Authors
- Lee, Yeon Ok; Shin, Jung-Won; Yi, Chunsik; Lee, Yun Hak; Sohn, Nak-Won; Kang, Chulhun; Kim, Jong Seung
- Issue Date
- 2014
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- CHEMICAL COMMUNICATIONS, v.50, no.43, pp.5741 - 5744
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMICAL COMMUNICATIONS
- Volume
- 50
- Number
- 43
- Start Page
- 5741
- End Page
- 5744
- ISSN
- 1359-7345
- Abstract
- We herein report a fluorescence probe 1 capable of detecting water-soluble oligomeric Ab aggregates and A beta fibrils. Upon injection into A beta(42)-challenged mouse brains, probe 1 shows increased fluorescence intensity, indicating its facile binding to extracellular Ab fibrils in brain tissues.
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