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DRD3 Gene rs6280 Polymorphism May Be Associated with Alcohol Dependence Overall and with Lesch Type I Alcohol Dependence in Koreans

Authors
Kang, Seung-GulLee, Bun-HeeLee, Jun-SeokChai, Young GyuKo, Kwang-PilLee, Heon-JeongHan, Dal Mu RiJi, HongJang, Gyeong-HoShin, Hye Eun
Issue Date
2014
Publisher
KARGER
Keywords
Alcohol dependence; DRD3 gene; Polymorphism; Lesch type I; Alcohol Use Disorders Identification Test; Koreans
Citation
NEUROPSYCHOBIOLOGY, v.69, no.3, pp.140 - 146
Indexed
SCIE
SCOPUS
Journal Title
NEUROPSYCHOBIOLOGY
Volume
69
Number
3
Start Page
140
End Page
146
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/101079
DOI
10.1159/000358062
ISSN
0302-282X
Abstract
Background: Several polymorphisnns of the dopamine D-3 receptor (DRD3) gene are reported to be involved in the susceptibility to alcoholism. Although the DRD3 rs6280 (Ser9-Gly) polymorphism plays an important role in various psychiatric disorders, findings regarding the association between this single-nucleotide polymorphism (SNP) and alcohol dependence (AD) have been inconsistent. Therefore, the present study investigated the association between the DRD3 gene rs6280 polymorphism with AD and Lesch type I AD in Korean subjects. Methods: The DRD3 rs6280 SNP was genotyped in a case-control sample comprising 245 AD patients and 130 healthy controls (HCs). Alcohol Use Disorders Identification Test (AUDIT) scores were also compared relative to genotype in all of the participants. Results: This SNP was significantly associated with both AD overall (chi(2) = 10.09 and p = 0.001, and chi(2) = 10.60 and p = 0.005, for the recessive and additive models, respectively) and with Lesch type I AD (chi(2) = 11.70 and p(r) = 0.001, and chi(2) = 11.70 and p = 0.003, for the recessive and additive models, respectively). The allele frequency differed significantly (chi(2) = 8.45, p = 0.004) between Lesch type I AD and HC subjects. The AUDIT total (F = 6.56, p = 0.011), hazardous alcohol use (F = 7.12, p = 0.008), dependence symptoms (F = 5.10, p = 0.025), and harmful alcohol use (F = 4.83, p = 0.029) scores were significantly higher in those who did not possess the S allele (genotype GG) than in those who did (genotypes SS +/- SG). Conclusions: The findings of this study suggest that the DRD3 rs6280 polymorphism is associated with the development of both AD overall and Lesch type I AD in Koreans. (C) 2014 S. Karger AG, Basel
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