Intratumoral phenotypic heterogeneity as an encourager of cancer invasion
- Authors
- Shin, Yoojin; Han, Sewoon; Chung, Euiheon; Chung, Seok
- Issue Date
- 2014
- Publisher
- OXFORD UNIV PRESS
- Citation
- INTEGRATIVE BIOLOGY, v.6, no.7, pp.654 - 661
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTEGRATIVE BIOLOGY
- Volume
- 6
- Number
- 7
- Start Page
- 654
- End Page
- 661
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/101158
- DOI
- 10.1039/c4ib00022f
- ISSN
- 1757-9694
- Abstract
- We present a novel in vitro breast tumor model to mimic intratumoral phenotypic heterogeneity based on a microfluidic system incorporating ECM scaffolds capable of providing a physiologically relevant tumor microenvironment. To study the regulation of invasive potentials by intratumoral subpopulation conditions, we developed heterogeneous cancer cell subpopulations by co-culturing two breast cancer cell types with distinct phenotypes, specifically, highly invasive and epithelial-like cancer cells. Our results indicate that intratumoral phenotypic heterogeneity acts as an encourager of cancer cell invasion through a 3D matrix depending on the neighboring ECM, with highly invasive cancer cells acting as the 'leader' and epithelial-like cancer cells as the 'follower', therefore enhancing the metastatic potential.
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Collections - College of Engineering > Department of Mechanical Engineering > 1. Journal Articles
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