Vitamin D receptor FokI, BsmI, ApaI, and TaqI polymorphisms and the susceptibility to breast cancer: a meta-analysis
- Authors
- Lee, Y. H.; Song, G. G.
- Issue Date
- 2014
- Publisher
- AEPRESS SRO
- Keywords
- breast cancer; vitamin D receptor; polymorphism; meta-analysis
- Citation
- NEOPLASMA, v.61, no.5, pp.607 - 616
- Indexed
- SCIE
SCOPUS
- Journal Title
- NEOPLASMA
- Volume
- 61
- Number
- 5
- Start Page
- 607
- End Page
- 616
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/101216
- DOI
- 10.4149/neo_2014_077
- ISSN
- 0028-2685
- Abstract
- The goal of this study is to examine whether vitamin D receptor (VDR) polymorphisms are associated with the susceptibility to breast cancer. Meta-analysis was employed to investigate the association between the VDR Fold, BsmI, ApaI, and TaqI polymorphisms and the incidence of breast cancer. A total of 32 comparative studies were evaluated in this meta-analysis, which included 17,067 patients and 20,843 controls. Meta-analysis of the VDR Fold polymorphism indicated an association between the incidence of breast cancer and the if genotype in Europeans (OR = 1.126, 95% CI = 1.026-1.243, p = 0.019) Furthermore, an association between the incidence of breast cancer and the VDR Fold polymorphism was found in the Europeans using the allele contrast, as well as the homozygote contrast. However, the meta-analysis indicated no association between breast cancer and the BsmI polymorphism in all study subjects, including the Europeans (OR for the B allele = 0.996, 95% CI = 0.964-1.097, p = 0.930, 1.026, 95% CI = 0.929-1.134, p = 0.610). Moreover, breast cancer incidence was not associated with the ApaI and Taq polymorphisms (OR for the A allele = 0.908, 95% CI = 0.763-1.041,p = 0.167, OR for the T allele = 0.972, 95% CI = 0.929-1.017,p = 0.221). This meta-analysis suggests that the VDR Fold polymorphism is associated with susceptibility to breast cancer in the European population.
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