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Anti-inflammatory constituents from the fruits of Vitex rotundifolia
- Authors
- Lee, Chul; Lee, Jin Woo; Jin, Qinghao; Lee, Hak Ju; Lee, Sung-Joon; Lee, Dongho; Lee, Myung Koo; Lee, Chong Kil; Hong, Jin Tae; Lee, Mi Kyeong; Hwang, Bang Yeon
- Issue Date
- 1-Nov-2013
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Vitex rotundifolia; Verbenaceae; Diterpene; Neolignan; Nitric oxide
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.23, no.21, pp.6010 - 6014
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 23
- Number
- 21
- Start Page
- 6010
- End Page
- 6014
- ISSN
- 0960-894X
- Abstract
- Three new diterpenes (7, 15 and 17) and two new neolignans (19 and 20) along with nineteen known compounds have been isolated from the fruits of Vitex rotundifolia. Their structures were elucidated by a combination of 1D and 2D NMR, HRESI-MS, and CD data. All isolates were tested for their inhibitory activities on LPS-induced nitric oxide production in RAW264.7 cells. Of these, compounds 3, 4, 7, 13, 15, 19, and 24 found to inhibit nitric oxide production with the IC50 values ranging from 11.3 to 24.5 mu M. (C) 2013 Elsevier Ltd. All rights reserved.
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Related Researcher
- Lee, Dong ho
- Department of Plant Biotechnology