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Relationships of Coagulation Factor XIII Activity with Cell-Type and Stage of Non-Small Cell Lung Cancer

Authors
Lee, Seung HeonSuh, In BumLee, Eun JooNur, Gyu YoungLee, Sung YongLee, Sang YeubShin, CholShim, Jae JeongIn, Kwang HoKang, Kyung HoYoo, Se HwaKim, Je Hyeong
Issue Date
1-11월-2013
Publisher
YONSEI UNIV COLL MEDICINE
Keywords
Factor XIII; histological type; neoplasm staging; non-small-cell lung carcinoma
Citation
YONSEI MEDICAL JOURNAL, v.54, no.6, pp.1394 - 1399
Indexed
SCIE
SCOPUS
KCI
Journal Title
YONSEI MEDICAL JOURNAL
Volume
54
Number
6
Start Page
1394
End Page
1399
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/101649
DOI
10.3349/ymj.2013.54.6.1394
ISSN
0513-5796
Abstract
Purpose: Factor XIII (FXIII), a thrombin-activated plasma transglutaminase zymogen, is involved in cancer development and progression through a triggered coagulation pathway. The aim of this study was to examine whether FM activity levels differed in non-small cell lung cancer (NSCLC) patients according to histological types and TNM stage when compared with healthy subjects. Materials and Methods: Twenty-eight NSCLC patients and 28 normal controls who had been individually age-, gender-, body mass index-, smoking status-, and smoking amount-matched were enrolled: 13 adenocarcinomas, 11 squamous cell carcinomas, and four undifferentiated NSCLCs; four stage I, two stage II, 12 stage III, and 10 stage IV NSCLCs. FXIII activity was measured using fluorescence-based protein arrays. Results: The median FXIII activity level of the NSCLC group [24.2 Loewy U/mL, interquartile range (IQR) 14.9-40.4 Loewy U/mL] was significantly higher than that of the healthy group (17.5 Loewy U/mL, IQR 12.6-26.4 Loewy U/mL) (p=0.01). There were no differences in FXIII activity between adenocarcinoma (median 18.6 Loewy U/mL) and squamous cell carcinoma (median 28.7 Loewy U/mL). NSCLC stage significantly influenced FXIII activity (p=0.02). The FXIII activity of patients with stage HI NSCLC (median 27.3 Loewy U/mL IQR 19.3-40.5 Loewy U/mL) was significantly higher than those of patients with stage I or II (median 14.0 Loewy U/mL, IQR 13.1-23.1 Loewy U/mL, p=0.04). FXIII activity was negatively correlated with aPTT in NSCLC patients (r=-0.38, p=0.04). Conclusion: Patients with advanced-stage NSCLC exhibited higher coagulation FXIII activity than healthy controls and early-stage NSCLC patients.
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