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Multilayer nanoparticles for sustained delivery of exenatide to treat type 2 diabetes mellitus
- Authors
- Kim, Jae Yeon; Lee, Hwanbum; Oh, Keun Sang; Kweon, Seho; Jeon, Ok-cheol; Byun, Youngro; Kim, Kwangmeyung; Kwon, Ick Chan; Kim, Sang Yoon; Yuk, Soon Hong
- Issue Date
- Nov-2013
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Core/shell nanoparticles; Layer-by-layer approach; Pluronics; Lipid bilayers; Sustained delivery of exenatide
- Citation
- BIOMATERIALS, v.34, no.33, pp.8444 - 8449
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOMATERIALS
- Volume
- 34
- Number
- 33
- Start Page
- 8444
- End Page
- 8449
- ISSN
- 0142-9612
- Abstract
- A method for the sustained delivery of exenatide was proposed using nanoparticles (NPs) with a core/shell structure. The interactions between lipid bilayers and Pluronics were utilized to form various NPs using a layer-by-layer approach. Transmittance electron microscopy and dynamic light scattering were used to examine the morphology of the NPs. The in vitro release pattern was observed as a function of changes in the structure of the NPs, and the structural integrity of exenatide released was examined by SDS-PAGE analysis. Pharmacokinetics and antidiabetic effects were also observed with the structural change of NPs using in vivo animal models. In vitro-in vivo correlation was discussed in relation to manipulation of the NP structures. (C) 2013 Elsevier Ltd. All rights reserved.
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Related Researcher
- Yuk, Soon Hong
- College of Pharmacy (Department of Pharmaceutical Science)